Low cholesterol targets cut cardiovascular events by 33%
empirical.healthThe 55 mg/dL target in this study is somewhere between the 1st and 5th percentile.
70 mg/dL (the control) is around the 10th percentile.
IMO, surprising that reductions at the low end still seem to yield such large benefits. I'd expect it to saturate much earlier.
Outlive is an excellent book, and one of the excellent discussions in that book is that there is no safe level of certain kinds of cholesterol. The details are fun do read up on.
It's somewhat bombastic, but a really excellent book for overall "next generation" health.
He also recommends people take rapamycin for longevity...
It's a while since I read the book but what I remember is him saying that he personally chooses to use it but the evidence is not strong enough to give a definite recommendation so basically, make your own choice.
Perhaps cholesterol is a (protective?) substance associated with a problem,
not the problem in and of itself.
ScholarlyArticle: "Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease" (2026) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
Do they control for arterial calcification?
Mentioning this again: Cyclodextrin apparently effectively treats atherosclerosis and arteriosclerosis. [1][2]
[1] "AI analysis of CT scans finds 42.9% of patients have coronary inflammation" https://news.ycombinator.com/item?id=50202532 :
> Can Beta-Cyclodextrin treat (calcified) atherosclerotic plaques? And gout?
> What percentage of cardiovascular "plaque" is sugar alcohol and thus apparently treatable with β or α cyclodextrin, in controls and patients with conditions like Arteriosclerosis and Atherosclerosis?
[2] "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming" (2016) https://www.science.org/doi/10.1126/scitranslmed.aad6100
Do steak and pork from Cheesecake Factory have cholesterol?