Ask HN: How To Be Goliath In A David Market?

In enterprise, Apple is David. The Goliath in enterprise is Microsoft, and if Microsoft wants Apple’s market in mobile enterprise, where apple is the Goliath and Microsoft is David, I would like to know the weaker side of these Goliaths, so that I can target them, All Goliaths will have some weak point where davids can target them, I see hundreds of startup companies around the world playing the role of David. Thanks!