Investigating the methodological foundation of lesion network mapping

Essentially, the LNM turns out to be unsuitable for various diagnostics it has been applied for:

> Our findings reveal a foundational limitation: at its core, LNM involves a repetitive sampling of one and the same FC matrix. As a result, it systematically maps sets of local brain changes—whether they are patient lesions, magnetic resonance imaging-derived alterations, synthetic or random—onto the same nonspecific properties of the used FC data, producing highly similar networks across conditions.