AI Antibody Design in 2025

Antibodies are proteins, so why is antibody design not just the same problem as mini-binder design? In most ways they are the same. The main difference is that the CDR loops that drive antibody binding are highly variable and do not benefit directly from evolutionary information the way other binding motifs do. Folding long CDR loops correctly is especially difficult.

Here I'll review the latest antibody design tools.