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Hydroxychloroquine found to be more potent than chloroquine to inhibit SARSCoV2

academic.oup.com

53 points by cybertronic 6 years ago · 8 comments

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eth0up 6 years ago

I ignorantly wonder (and wander beyond my territory) if zinc has a role here, considering chloroquine's apparent ability to allow it to become intracellular and work thusly against the virus, which it seems to do with co-administration.

For an intelligent, less befuddled perspective, see medcram lecture 34 https://m.youtube.com/watch?v=U7F1cnWup9M

cwkoss 6 years ago

It seems like the title may be misleading:

"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."

This seems like:

a. This would have no prophylactic benefit (to avoid infection or reduce early symptoms)

b. The benefit would only apply to people who are already in the late stages and experiencing a cytokine storm

As hydroxycholoquine is immunosuppressant, I might suspect that its use in non-critical cases could actually worsen outcomes by suppressing the functioning immune response. As someone who was looking into it as a potential tool in the prep kit, I think this is likely a drug that is best administered only at the discretion of a doctor.

Would love to hear opinions from others who are more knowledgable though.

8bitsrule 6 years ago

"Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV."

https://www.nature.com/articles/s41422-020-0282-0 [04 February 2020, https://doi.org/10.1038/s41422-020-0282-0]

A generic anti-malarial on WHO's Essential Medicines list, about 100 times more expensive in the US (WP)

29athrowaway 6 years ago

In vitro, not in vivo.

  • jamesblonde 6 years ago

    But we haven't had a readout on the Chloroquine trials yet. Early results say they are promising. So, it's not a huge leap to say there is a good chance that Hydroxychloroquine is even better (based on in-vitro results) and has a better safety profile.

    It's easier to buy Chloroquine online though, than Hydroxychloroquine.

throwGuardian 6 years ago

Is SARSCov2 == COVID-19?

Or is SARSCov2 ~= COVID-19?

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