NoSQL at Twitter (infoq)
infoq.comGreat talk on Twitter architecture as of Nov. 2010 by @rk. A lot of innovative high scale open source code and ideas are coming out of Twitter that will have (and already have had) a trickle down effect on the greater tech community dealing with these issues.
I particularly appreciated the dissection of snowflake, their distributed unique id generator, their realtime use of cassandra for distributed counters and their upstream patches for redis.