Nuitka: A Python compiler
nuitka.netTalk Python has a podcast with an interview of the Nuitka developer https://talkpython.fm/episodes/show/172/nuitka-a-full-python...
Wow, this is really something! Too early to tell how this will go, but I really hope this thing takes off!
It's actually been around for quite a while, just not getting attention.
The last time I checked, it didn't support Django. Migrations didn't work. Don't know whether it works or not now.
It currently claims to have 100% support of most modern versions of Python (and they're working on 3.7). That would suggest that it used to not work and now does, but I haven't tried.