Genealogy records reveal how a harmful mutation can hide from natural selection

290 years is really the blink of an eye in terms of human evolution, and so the title line is a little misleading. Wait another three thousand years and it's likely we will be able to measure an evolutionary effect. The article notes that some women get this disorder as a result of carrying the allele that it is associated with, but at a rate that's around 1:10 relative to males, so maybe it's just a matter of more time. Also, selection in humans can occur on the whole family not just on individuals, so families with sick males might have a disadvantage, but the effect is apparently too small to measure in this data.