Aging as a glitch in the matrix

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Extracellular matrix

Nature Aging volume 5, pages 2365–2366 (2025)Cite this article

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Yi and colleagues demonstrate that age-induced degradation of extracellular matrix generates elastin-derived fragments that activate the innate and adaptive immune system, which evokes systemic inflammaging.

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Fig. 1: Aged-induced ECM fragmentation fuels inflammaging.

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Authors and Affiliations

  1. Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA

    Seung Mo Jin & Jennifer H. Elisseeff

  2. Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jennifer H. Elisseeff

Authors

  1. Seung Mo Jin
  2. Jennifer H. Elisseeff

Corresponding author

Correspondence to Jennifer H. Elisseeff.

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Competing interests

The authors declare no competing interests.

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Jin, S.M., Elisseeff, J.H. Aging as a glitch in the matrix. Nat Aging 5, 2365–2366 (2025). https://doi.org/10.1038/s43587-025-01009-7

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  • DOI: https://doi.org/10.1038/s43587-025-01009-7