Data availability
These data are not publicly accessible due to ethical and institutional restrictions safeguarding research subject privacy. De-identified recipient data supporting the findings of this study are available upon request from the corresponding author, subject to ethics and institutional approval. Requests will be reviewed within 2 weeks.
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Acknowledgements
We thank the family of the decedent for their invaluable contribution to the advancement of lung xenotransplantation and scientific research. We also thank the clinical and laboratory teams at the First Affiliated Hospital of Guangzhou Medical University and the National Clinical Centre for Respiratory Disease, including the lung xenotransplantation clinical team (Y. Zeng, J. Mao, L. Wang, W. Shen, J. Zhang, T. Xing, Y. Xue, J. Fan, Y. Ouyang and X. Zhang), the nursing team (Y. Chen, D. Huang, R. Li, X. Li, M. Kuang and X. Li), anesthesiologist Y. Zhou, laboratory staff (W. Wang, L. Liu, Z. Huang and M. Yu) and the organ procurement organization personnel (L. Wang, L. Wang, Y. Wang and K. Li) for their unwavering support. We acknowledge L. Burdorf and C. Laird’s team for their pioneering work on NHP lung xenotransplantation, which inspired this research, particularly in the experimental design.
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D.P. is a co-founder of Chengdu Clonorgan Biotechnology Co. Ltd, Chengdu, China. The other authors declare competing interests.
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He, J., Shi, J., Yang, C. et al. Pig-to-human lung xenotransplantation into a brain-dead recipient. Nat Med 31, 3388–3393 (2025). https://doi.org/10.1038/s41591-025-03861-x
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DOI: https://doi.org/10.1038/s41591-025-03861-x