Biswas, R. & Hall, D. A. Prevalence, incidence, and risk factors for tinnitus. Curr. Top. Behav. Neurosci. 51, 3–28 (2021).
Biswas, R. et al. Tinnitus prevalence in Europe: a multi-country cross-sectional population study. Lancet Reg. Health Eur. 12, 100250 (2022).
Jarach, C. M. et al. Global prevalence and incidence of tinnitus: a systematic review and meta-analysis. JAMA Neurol. 79, 888–900 (2022). This paper provides the most rigorous, large-scale synthesis of worldwide tinnitus prevalence and incidence, giving clinicians, researchers and policy-makers a reliable baseline for how common tinnitus is and how often new cases arise.
De Ridder, D. et al. Tinnitus and tinnitus disorder: theoretical and operational definitions (an international multidisciplinary proposal). Prog. Brain Res. 260, 1–25 (2021). This paper establishes internationally agreed theoretical and operational definitions that clearly distinguish ‘tinnitus’ from ‘tinnitus disorder’, enabling more consistent diagnosis, research design and comparison of results across studies.
Elgoyhen, A. B., Langguth, B., De Ridder, D. & Vanneste, S. Tinnitus: perspectives from human neuroimaging. Nat. Rev. Neurosci. 16, 632–642 (2015).
Sedley, W., Friston, K. J., Gander, P. E., Kumar, S. & Griffiths, T. D. An integrative tinnitus model based on sensory precision. Trends Neurosci. 39, 799–812 (2016).
Maihoub, S., Mavrogeni, P., Molnar, V. & Molnar, A. Tinnitus and its comorbidities: a comprehensive analysis of their relationships. J. Clin. Med. 14, 1285 (2025).
Langguth, B., Kreuzer, P. M., Kleinjung, T. & De Ridder, D. Tinnitus: causes and clinical management. Lancet Neurol. 12, 920–930 (2013). A landmark clinical review that synthesizes tinnitus causes, mechanisms and evidence-based management into a practical framework that has guided modern diagnosis and treatment.
McCormack, A., Edmondson-Jones, M., Somerset, S. & Hall, D. A systematic review of the reporting of tinnitus prevalence and severity. Hear. Res. 337, 70–79 (2016).
Baguley, D., McFerran, D. & Hall, D. Tinnitus. Lancet 382, 1600–1607 (2013).
Gallus, S. et al. Prevalence and determinants of tinnitus in the Italian adult population. Neuroepidemiology 45, 12–19 (2015).
Batts, S. & Stankovic, K. M. Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis. Lancet Reg. Health Am. 29, 100659 (2024).
Shargorodsky, J., Curhan, G. C. & Farwell, W. R. Prevalence and characteristics of tinnitus among US adults. Am. J. Med. 123, 711–718 (2010).
GBD 2021 Forecasting Collaborators. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the global burden of disease study 2021. Lancet 403, 2204–2256 (2024).
GBD 2019 Ageing Collaborators. Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. BMJ 376, e068208 (2022).
Jarach, C. M., Simoes, J. P., Schlee, W., Langguth, B. & Gallus, S. Urgent support is needed for more tinnitus research. J. Epidemiol. 35, 382–383 (2025).
Biswas, R. et al. Low evidence for tinnitus risk factors: a systematic review and meta-analysis. J. Assoc. Res. Otolaryngol. 24, 81–94 (2023).
Tan, C. M., Lecluyse, W., McFerran, D. & Meddis, R. Tinnitus and patterns of hearing loss. J. Assoc. Res. Otolaryngol. 14, 275–282 (2013).
Cederroth, C. R., Trpchevska, N. & Langguth, B. A new buzz for tinnitus-it’s in the genes! JAMA Otolaryngol. Head Neck Surg. 146, 1025–1026 (2020).
Cederroth, C. R. et al. Association between hyperacusis and tinnitus. J. Clin. Med. 9, 2412 (2020).
Aazh, H., Moore, B. C., Lammaing, K. & Cropley, M. Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: patients’ evaluations of the effectiveness of treatments. Int. J. Audiol. 55, 514–522 (2016).
Kujawa, S. G. & Liberman, M. C. Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J. Neurosci. 29, 14077–14085 (2009).
Chen, F., Zhao, F., Mahafza, N. & Lu, W. Detecting noise-induced cochlear synaptopathy by auditory brainstem response in tinnitus patients with normal hearing thresholds: a meta-analysis. Front. Neurosci. 15, 778197 (2021).
Gopinath, B., McMahon, C. M., Rochtchina, E., Karpa, M. J. & Mitchell, P. Risk factors and impacts of incident tinnitus in older adults. Ann. Epidemiol. 20, 129–135 (2010).
Kacprzyk, A. et al. The impact of mobile phone use on tinnitus: a systematic review and meta-analysis. Bioelectromagnetics 42, 105–114 (2021).
Vasilkov, V. et al. Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus. Sci. Rep. 13, 19870 (2023).
Sismanis, A. Pulsatile tinnitus. Otolaryngol. Clin. North Am. 36, 389–402 (2003).
Edvall, N. K. et al. Impact of temporomandibular joint complaints on tinnitus-related distress. Front. Neurosci. 13, 879 (2019).
Lee, C. F. et al. Increased risk of tinnitus in patients with temporomandibular disorder: a retrospective population-based cohort study. Eur. Arch. Otorhinolaryngol. 273, 203–208 (2016).
Stohler, N. A., Reinau, D., Jick, S. S., Bodmer, D. & Meier, C. R. A study on the epidemiology of tinnitus in the United Kingdom. Clin. Epidemiol. 11, 855–871 (2019).
Deklerck, A. N., Debacker, J. M., Keppler, H. & Dhooge, I. J. M. Identifying non-otologic risk factors for tinnitus: a systematic review. Clin. Otolaryngol. 45, 775–787 (2020).
Levine, R. A., Nam, E. C., Oron, Y. & Melcher, J. R. Evidence for a tinnitus subgroup responsive to somatosensory based treatment modalities. Prog. Brain Res. 166, 195–207 (2007).
Michiels, S. Somatosensory tinnitus: recent developments in diagnosis and treatment. J. Assoc. Res. Otolaryngol. 24, 465–472 (2023). This is an important paper synthesizing the latest evidence on somatosensory tinnitus, highlighting how to identify it clinically and which targets are most promising for treatment.
Lugo, A. et al. Relationship between headaches and tinnitus in a Swedish study. Sci. Rep. 10, 8494 (2020).
Hwang, J. H., Tsai, S. J., Liu, T. C., Chen, Y. C. & Lai, J. T. Association of tinnitus and other cochlear disorders with a history of migraines. JAMA Otolaryngol. Head Neck Surg. 144, 712–717 (2018).
Sindhusake, D. et al. Risk factors for tinnitus in a population of older adults: the Blue Mountains Hearing Study. Ear Hear. 24, 501–507 (2003).
Campello, C. P. et al. Migraine associated with tinnitus and hearing loss in adults: a systematic review. Int. J. Audiol. 63, 1–7 (2024).
Langguth, B. et al. Tinnitus and headache. Biomed. Res. Int. 2015, 797416 (2015).
Gu, H., Kong, W., Yin, H. & Zheng, Y. Prevalence of sleep impairment in patients with tinnitus: a systematic review and single-arm meta-analysis. Eur. Arch. Otorhinolaryngol. 279, 2211–2221 (2022).
Koo, M. & Hwang, J. H. Risk of tinnitus in patients with sleep apnea: a nationwide, population-based, case-control study. Laryngoscope 127, 2171–2175 (2017).
Fujii, K. et al. Prevalence of tinnitus in community-dwelling Japanese adults. J. Epidemiol. 21, 299–304 (2011).
Nondahl, D. M. et al. Tinnitus and its risk factors in the Beaver Dam offspring study. Int. J. Audiol. 50, 313–320 (2011).
Homer, B. J. et al. Statins and their effect on hearing: an all of us database study. Ann. Otol. Rhinol. Laryngol. 135, 20–26 (2026).
Maas, I. L. et al. Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genet. Med. 19, 1007–1012 (2017).
Bogo, R. et al. Prevalence, incidence proportion, and heritability for tinnitus: a longitudinal twin study. Ear Hear. 38, 292–300 (2017).
Cederroth, C. R. et al. Association of genetic vs environmental factors in Swedish adoptees with clinically significant tinnitus. JAMA Otolaryngol. Head Neck Surg. 145, 222–229 (2019).
Trpchevska, N. et al. Sex-dependent aggregation of tinnitus in Swedish families. J. Clin. Med. 9, 3812 (2020).
Amanat, S. et al. Burden of rare variants in synaptic genes in patients with severe tinnitus: an exome based extreme phenotype study. EBioMedicine 66, 103309 (2021).
Clifford, R. E. et al. Genetic architecture distinguishes tinnitus from hearing loss. Nat. Commun. 15, 614 (2024).
Perez-Carpena, P., Lopez-Escamez, J. A. & Gallego-Martinez, A. A systematic review on the genetic contribution to tinnitus. J. Assoc. Res. Otolaryngol. 25, 13–33 (2024).
Amanat, S., Gallego-Martinez, A. & Lopez-Escamez, J. A. Genetic inheritance and its contribution to tinnitus. Curr. Top. Behav. Neurosci. 51, 29–47 (2021).
Martin-Lagos, J. et al. Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants. Eur. Arch. Otorhinolaryngol. 281, 4071–4080 (2024).
Xie, C. et al. Genome-wide association study identifies new loci associated with noise-induced tinnitus in Chinese populations. BMC Genom. Data 22, 31 (2021).
Hasson, D., Theorell, T., Westerlund, H. & Canlon, B. Prevalence and characteristics of hearing problems in a working and non-working Swedish population. J. Epidemiol. Commun. Health 64, 453–460 (2010).
Theodoroff, S. M. & Folmer, R. L. Hearing loss associated with long-term exposure to high-speed dental handpieces. Gen. Dent. 63, 71–76 (2015).
Halevi-Katz, D. N., Yaakobi, E. & Putter-Katz, H. Exposure to music and noise-induced hearing loss (NIHL) among professional pop/rock/jazz musicians. Noise Health 17, 158–164 (2015).
Engdahl, B. & Aarhus, L. Prevalence and predictors of self-reported hearing aid use and benefit in Norway: the HUNT study. BMC Public Health 24, 474 (2024).
Wadhwa, S., Jain, S. & Patil, N. The role of diet and lifestyle in the tinnitus management: a comprehensive review. Cureus 16, e59344 (2024).
Jarach, C. M. et al. The role of diet in tinnitus onset: a hospital-based case-control study from Italy. Nutrients 15, 621 (2023).
Glicksman, J. T., Curhan, S. G. & Curhan, G. C. A prospective study of caffeine intake and risk of incident tinnitus. Am. J. Med. 127, 739–743 (2014).
Tang, D. et al. Associations between intake of dietary flavonoids and the 10-year incidence of tinnitus in older adults. Eur. J. Nutr. 61, 1957–1964 (2022).
Tang, D. et al. Dietary fibre intake and the 10-year incidence of tinnitus in older adults. Nutrients 13, 4126 (2021).
Nelson, J. J. & Chen, K. The relationship of tinnitus, hyperacusis, and hearing loss. Ear Nose Throat J. 83, 472–476 (2004).
Bernal-Robledano, A., Parra-Perez, A. M., Moleon, M. D. C., Lopez-Escámez, J. A. & Perez-Carpena, P. Personality traits associated with tinnitus: a systematic review and contributing genetic variants. Neurosci. Biobehav. Rev. 178, 106389 (2025).
Salazar, J. W. et al. Depression in patients with tinnitus: a systematic review. Otolaryngol. Head Neck Surg. 161, 28–35 (2019).
Meijers, S. M., Rademaker, M., Meijers, R. L., Stegeman, I. & Smit, A. L. Correlation between chronic tinnitus distress and symptoms of depression: a systematic review. Front. Neurol. 13, 870433 (2022).
Langguth, B. A review of tinnitus symptoms beyond ‘ringing in the ears’: a call to action. Curr. Med. Res. Opin. 27, 1635–1643 (2011).
Shore, S. E., Roberts, L. E. & Langguth, B. Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment. Nat. Rev. Neurol. 12, 150–160 (2016). This paper frames tinnitus as a consequence of maladaptive neuroplasticity, linking triggers to underlying neural mechanisms and pointing to mechanistically targeted treatments rather than purely symptomatic management.
Wang, Y. et al. The characteristics of cognitive impairment in subjective chronic tinnitus. Brain Behav. 8, e00918 (2018).
Cima, R. F. F. Bothersome tinnitus: cognitive behavioral perspectives. HNO 66, 369–374 (2018).
Lee, H. Y. Beyond hearing loss: does tinnitus cause cognitive impairment? Clin. Exp. Otorhinolaryngol. 13, 2–3 (2020).
MacDonald, C. et al. Tinnitus, suicide, and suicidal ideation: a scoping review of primary research. Brain Sci. 13, 1496 (2023).
McCray, L. R. et al. Suicidal ideation and behaviors in adults with tinnitus: a systematic review and meta-analysis. Laryngoscope 135, 2653–2661 (2025).
Seo, J. H., Kang, J. M., Hwang, S. H., Han, K. D. & Joo, Y. H. Relationship between tinnitus and suicidal behaviour in Korean men and women: a cross-sectional study. Clin. Otolaryngol. 41, 222–227 (2016).
Biswas, R., Lugo, A., Gallus, S., Akeroyd, M. A. & Hall, D. A. Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages. Hear. Res. 377, 330–338 (2019).
Schaette, R. & McAlpine, D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J. Neurosci. 31, 13452–13457 (2011).
Jastreboff, P. J. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci. Res. 8, 221–254 (1990).
House, J. W. & Brackmann, D. E. Tinnitus: surgical treatment. Ciba Found. Symp. 85, 204–216 (1981).
Noreña, A. J. & Farley, B. J. Tinnitus-related neural activity: theories of generation, propagation, and centralization. Hearing Res. 295, 161–171 (2013).
Noreña, A. J. An integrative model of tinnitus based on a central gain controlling neural sensitivity. Neurosci. Biobehav. Rev. 35, 1089–1109 (2011).
Zeng, F. G. An active loudness model suggesting tinnitus as increased central noise and hyperacusis as increased nonlinear gain. Hear. Res. 295, 172–179 (2013).
van der Loo, E. et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS ONE 4, e7396 (2009).
Suga, N. Sharpening of frequency tuning by inhibition in the central auditory system: tribute to Yasuji Katsuki. Neurosci. Res. 21, 287–299 (1995).
Llinás, R., Urbano, F. J., Leznik, E., Ramírez, R. R. & van Marle, H. J. Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci. 28, 325–333 (2005).
Llinás, R. R., Ribary, U., Jeanmonod, D., Kronberg, E. & Mitra, P. P. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc. Natl Acad. Sci. USA 96, 15222–15227 (1999).
Vanneste, S., Song, J.-J. & De Ridder, D. Thalamocortical dysrhythmia detected by machine learning. Nat. Commun. 9, 1103 (2018).
Wang, Y. et al. Theta–beta/gamma coupling identifies bothersome tinnitus induced by thalamocortical dysrhythmia. Brain Behav. 15, e70437 (2025).
Hwang, J. H., Chen, J. C., Yang, S. Y., Wang, M. F. & Chan, Y. C. Expression of tumor necrosis factor-α and interleukin-1β genes in the cochlea and inferior colliculus in salicylate-induced tinnitus. J. Neuroinflammation 8, 30 (2011).
Wang, W. et al. Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models. PLoS Biol. 17, e3000307 (2019).
Mennink, L. M., Aalbers, M. W., van Dijk, P. & van Dijk, J. M. C. The role of inflammation in tinnitus: a systematic review and meta-analysis. J. Clin. Med. 11, 1000 (2022).
Adcock, K. S. & Vanneste, S. Neuroinflammation in tinnitus. Curr. Otorhinolaryngol. Rep. 10, 322–328 (2022). This article consolidates emerging evidence that neuroinflammatory processes may contribute to tinnitus, opening up new mechanistic hypotheses and potential anti-inflammatory or immunomodulatory treatment targets.
Krauss, P. et al. Stochastic resonance controlled upregulation of internal noise after hearing loss as a putative cause of tinnitus-related neuronal hyperactivity. Front. Neurosci. 10, 597 (2016).
Schilling, A. et al. Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception. Brain 146, 4809–4825 (2023).
Krauss, P. et al. Adaptive stochastic resonance for unknown and variable input signals. Sci. Rep. 7, 2450 (2017).
De Ridder, D. & Vanneste, S. The Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain: a perspective. Prog. Brain Res. 262, 309–334 (2021).
Eggermont, J. J. & Roberts, L. E. The neuroscience of tinnitus. Trends Neurosci. 27, 676–682 (2004).
Shahsavarani, S., Schmidt, S. A., Khan, R. A., Tai, Y. & Husain, F. T. Salience, emotion, and attention: the neural networks underlying tinnitus distress revealed using music and rest. Brain Res. 1755, 147277 (2021).
Møller, A. R., Møller, M. B. & Yokota, M. Some forms of tinnitus may involve the extralemniscal auditory pathway. Laryngoscope 102, 1165–1171 (1992).
Shore, S. E. & Zhou, J. Somatosensory influence on the cochlear nucleus and beyond. Hear. Res. 216–217, 90–99 (2006).
Leaver, A. M. et al. Cortico-limbic morphology separates tinnitus from tinnitus distress. Front. Syst. Neurosci. 6, 21 (2012).
Mühlau, M. et al. Structural brain changes in tinnitus. Cereb. Cortex 16, 1283–1288 (2006).
Vanneste, S., Alsalman, O. & De Ridder, D. COMT and the neurogenetic architecture of hearing loss induced tinnitus. Hear. Res. 365, 1–15 (2018).
Rauschecker, J. P., May, E. S., Maudoux, A. & Ploner, M. Frontostriatal gating of tinnitus and chronic pain. Trends Cogn. Sci. 19, 567–578 (2015).
Rauschecker, J. P., Leaver, A. M. & Muhlau, M. Tuning out the noise: limbic-auditory interactions in tinnitus. Neuron 66, 819–826 (2010).
Morse, K. & Vander Werff, K. R. Cortical auditory evoked potential indices of impaired sensory gating in people with chronic tinnitus. Ear Hear. 45, 730–741 (2024).
De Ridder, D., Adhia, D. & Vanneste, S. The anatomy of pain and suffering in the brain and its clinical implications. Neurosci. Biobehav. Rev. 130, 125–146 (2021).
Eggermont, J. J. Tinnitus: neurobiological substrates. Drug Discov. Today 10, 1283–1290 (2005).
Vanneste, S., Alsalman, O. & De Ridder, D. Top-down and bottom-up regulated auditory phantom perception. J. Neurosci. 39, 364 (2019). This article provides a clear neural framework for tinnitus as an auditory phantom percept emerging from interactions between bottom-up sensory signals and top-down predictive or attention control, guiding mechanistically grounded research and interventions.
Vanneste, S. & De Ridder, D. The auditory and non-auditory brain areas involved in tinnitus. An emergent property of multiple parallel overlapping subnetworks. Front. Syst. Neurosci. 6, 31 (2012).
De Ridder, D. et al. An integrative model of auditory phantom perception: tinnitus as a unified percept of interacting separable subnetworks. Neurosci. Biobehav. Rev. 44, 16–32 (2014).
Mohan, A. & Vanneste, S. Adaptive and maladaptive neural compensatory consequences of sensory deprivation—from a phantom percept perspective. Prog. Neurobiol. 153, 1–17 (2017).
Mohan, A., De Ridder, D. & Vanneste, S. Graph theoretical analysis of brain connectivity in phantom sound perception. Sci. Rep. 6, 19683 (2016).
Adamchic, I., Hauptmann, C. & Tass, P. A. Changes of oscillatory activity in pitch processing network and related tinnitus relief induced by acoustic CR neuromodulation. Front. Syst. Neurosci. 6, 18 (2012).
Schecklmann, M. et al. Neural correlates of tinnitus duration and distress: a positron emission tomography study. Hum. Brain Mapp. 34, 233–240 (2013).
Schlee, W., Hartmann, T., Langguth, B. & Weisz, N. Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci. 10, 11 (2009).
Schlee, W. et al. Mapping cortical hubs in tinnitus. BMC Biol. 7, 80 (2009).
Hullfish, J., Abenes, I., Yoo, H. B., De Ridder, D. & Vanneste, S. Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception. Hum. Brain Mapp. 40, 2241–2251 (2019).
Joos, K., Vanneste, S. & De Ridder, D. Disentangling depression and distress networks in the tinnitus brain. PLoS ONE 7, e40544 (2012).
Chen, Y. C. et al. Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network. Neuropsychiatr. Dis. Treat. 14, 1919–1927 (2018).
Sommerhalder, N. et al. Deficient central mechanisms in tinnitus: exploring the impact on speech comprehension and executive functions. Hear. Res. 440, 108914 (2023).
De Ridder, D., Elgoyhen, A. B., Romo, R. & Langguth, B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc. Natl Acad. Sci. USA 108, 8075–8080 (2011).
Husain, F. T. Neural networks of tinnitus in humans: elucidating severity and habituation. Hear. Res. 334, 37–48 (2016).
Husain, F. T. & Khan, R. A. Review and perspective on brain bases of tinnitus. J. Assoc. Res. Otolaryngol. 24, 549–562 (2023).
Husain, F. T. & Schmidt, S. A. Using resting state functional connectivity to unravel networks of tinnitus. Hear. Res. 307, 153–162 (2014).
De Ridder, D., Vanneste, S., Song, J. J. & Adhia, D. Tinnitus and the triple network model: a perspective. Clin. Exp. Otorhinolaryngol. 15, 205–212 (2022).
Mohan, A., De Ridder, D., Idiculla, R., Dsouza, C. & Vanneste, S. Distress-dependent temporal variability of regions encoding domain-specific and domain-general behavioral manifestations of phantom percepts. Eur. J. Neurosci. 48, 1743–1764 (2018).
Mohan, A., Alexandra, S. J., Johnson, C. V., De Ridder, D. & Vanneste, S. Effect of distress on transient network dynamics and topological equilibrium in phantom sound perception. Prog. Neuropsychopharmacol. Biol. Psychiatry 84, 79–92 (2018).
Soares, J. M. et al. Stress-induced changes in human decision-making are reversible. Transl. Psychiatry 2, e131 (2012).
De Ridder, D., Vanneste, S. & Congedo, M. The distressed brain: a group blind source separation analysis on tinnitus. PLoS ONE 6, e24273 (2011).
Vanneste, S. & De Ridder, D. Stress-related functional connectivity changes between auditory cortex and cingulate in tinnitus. Brain Connect. 5, 371–383 (2015).
De Ridder, D., Congedo, M. & Vanneste, S. The neural correlates of subjectively perceived and passively matched loudness perception in auditory phantom perception. Brain Behav. 5, e00331 (2015).
Kim, D. K. et al. Diagnostic value and clinical significance of stress hormones in patients with tinnitus. Eur. Arch. Otorhinolaryngol. 271, 2915–2921 (2014).
Szczepek, A. J. & Mazurek, B. Neurobiology of stress-induced tinnitus. Curr. Top. Behav. Neurosci. 51, 327–347 (2021).
Al-Mana, D., Ceranic, B., Djahanbakhch, O. & Luxon, L. M. Hormones and the auditory system: a review of physiology and pathophysiology. Neuroscience 153, 881–900 (2008).
Kraus, K. S. & Canlon, B. Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus. Hear. Res. 288, 34–46 (2012).
Friston, K. & Kiebel, S. Predictive coding under the free-energy principle. Philos. Trans. R. Soc. Lond. B 364, 1211–1221 (2009).
De Ridder, D., Vanneste, S. & Freeman, W. The Bayesian brain: phantom percepts resolve sensory uncertainty. Neurosci. Biobehav. Rev. 44, 4–15 (2014).
Corlett, P. R. et al. Hallucinations and strong priors. Trends Cogn. Sci. 23, 114–127 (2019).
Langguth, B., de Ridder, D., Schlee, W. & Kleinjung, T. Tinnitus: clinical insights in its pathophysiology-a perspective. J. Assoc. Res. Otolaryngol. 25, 249–258 (2024).
McKenna, L., Handscomb, L., Hoare, D. J. & Hall, D. A. A scientific cognitive-behavioral model of tinnitus: novel conceptualizations of tinnitus distress. Front. Neurol. 5, 196 (2014).
Wong, W. K. & Lee, M. F. Middle ear myoclonus: systematic review of results and complications for various treatment approaches. Am. J. Otolaryngol. 43, 103228 (2022).
Sanders, J. V., Keigher, K., Oliver, M., Lopes, D. & Joshi, K. An evidence-based pulsatile tinnitus clinical workflow: a systematic review of literature. Interv. Neuroradiol. https://doi.org/10.1177/15910199251380393 (2025).
Jain, V. et al. Expert Panel on Neurological Imaging. ACR Appropriateness Criteria® Tinnitus: 2023 Update. J. Am. Coll. Radiol. 20, S574–S591 (2023).
Settecase, F. & Rayz, V. L. Advanced vascular imaging techniques. Handb. Clin. Neurol. 176, 81–105 (2021).
Stahl, J. et al. Flow-based simulation in transverse sinus stenosis pre- and post-stenting: pressure prediction accuracy, hemodynamic complexity, and relationship to pulsatile tinnitus. J. Neurointerv. Surg. 18, 485–492 (2026).
Mu, Z. et al. Multiphysics interaction analysis of the therapeutic effects of the sigmoid sinus wall reconstruction in patients with venous pulsatile tinnitus. Bioengineering 10, 715 (2023).
Alvear, A. S., Limón, G. A., Reyes Martínez, L. M., Gómez, R. S. & Serrano Arias, F. E. Pulsatile tinnitus: a narrative review. J. Int. Adv. Otol. 21, e251923 (2025).
Bance, M., Tysome, J. R. & Smith, M. E. Patulous eustachian tube (PET), a practical overview. World J. Otorhinolaryngol. Head Neck Surg. 5, 137–142 (2019).
Michiels, S. et al. Diagnostic criteria for somatosensory tinnitus: a delphi process and face-to-face meeting to establish consensus. Trends Hear. 22, 2331216518796403 (2018).
Han, J. H. et al. Clinical factors associated with prognosis of tinnitus and aural fullness after sudden sensorineural hearing loss. Otol. Neurotol. 44, 432–437 (2023).
Newman, C. W., Jacobson, G. P. & Spitzer, J. B. Development of the tinnitus handicap inventory. Arch. Otolaryngol. Head Neck Surg. 122, 143–148 (1996).
Meikle, M. B. et al. The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus. Ear Hear. 33, 153–176 (2012).
Hoekstra, C. E., Wesdorp, F. M. & van Zanten, G. A. Socio-demographic, health, and tinnitus related variables affecting tinnitus severity. Ear Hear. 35, 544–554 (2014).
Langguth, B. et al. Consensus for tinnitus patient assessment and treatment outcome measurement: tinnitus research initiative meeting, Regensburg, July 2006. Prog. Brain Res. 166, 525–536 (2007).
Hobeika, L. et al. Tinnitus risk factors and its evolution over time. Nat. Commun. 16, 4244 (2025).
Vielsmeier, V. et al. The relevance of the high frequency audiometry in tinnitus patients with normal hearing in conventional pure-tone audiometry. Biomed. Res. Int. 2015, 302515 (2015).
Adams, M. E., Huang, T. C., Nagarajan, S. & Cheung, S. W. Tinnitus neuroimaging. Otolaryngol. Clin. N. Am. 53, 583–603 (2020).
Hertzano, R., Teplitzky, T. B. & Eisenman, D. J. Clinical evaluation of tinnitus. Neuroimaging Clin. N. Am. 26, 197–205 (2016).
Tunkel, D. E. et al. Clinical practice guideline: tinnitus. Otolaryngol. Head Neck Surg. 151, S1–S40 (2014).
Cima, R. F. F. et al. A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO 67, 10–42 (2019). Delivers a comprehensive, evidence-based European consensus guideline that standardizes tinnitus diagnostics, assessment tools and recommended treatments across multidisciplinary clinical practice.
Sherlock, L. P. et al. Clinical practice guideline for management of tinnitus: recommendations from the US VA/DOD clinical practice guideline work group. JAMA Otolaryngol. Head Neck Surg. 151, 513–520 (2025).
Lewis, S., Chowdhury, E., Stockdale, D., Kennedy, V. & Guideline, C. Assessment and management of tinnitus: summary of NICE guidance. BMJ 368, m976 (2020).
Tikka, C. et al. Interventions to prevent occupational noise-induced hearing loss. Cochrane Database Syst. Rev. 7, CD006396 (2017).
Yang, S. W., Xu, W., Chen, L. & Fang, S. B. Associations between tinnitus and hearing loss among noise-exposed workers in the United States from 1999 to 2020: a cross-sectional study. J. Otolaryngol. Head Neck Surg. 54, 19160216251347597 (2025).
Langguth, B. & De Ridder, D. Minimal clinically important difference of tinnitus outcome measurement instruments — a scoping review. J. Clin. Med. 12, 7117 (2023).
Hall, D. A., Mehta, R. L. & Fackrell, K. How to choose between measures of tinnitus loudness for clinical research? A report on the reliability and validity of an investigator-administered test and a patient-reported measure using baseline data collected in a phase IIa drug trial. Am. J. Audiol. 26, 338–346 (2017).
Adamchic, I., Langguth, B., Hauptmann, C. & Tass, P. A. Psychometric evaluation of visual analog scale for the assessment of chronic tinnitus. Am. J. Audiol. 21, 215–225 (2012).
Mazurek, B. et al. Chronic tinnitus. Dtsch. Arztebl. Int. 119, 219–225 (2022).
Kleinjung, T., Peter, N., Schecklmann, M. & Langguth, B. The current state of tinnitus diagnosis and treatment: a multidisciplinary expert perspective. J. Assoc. Res. Otolaryngol. 25, 413–425 (2024). This paper captures a current, multidisciplinary expert consensus on best-practice tinnitus assessment and management, summarizing what is clinically actionable now while highlighting key gaps and priorities for future research.
Xiang, T. et al. Effect of educational counseling alone on people with tinnitus: meta-analysis of randomized controlled trials. Patient Educ. Couns. 103, 44–54 (2020).
Perreau, A., Tyler, R. S. & Corts, D. Development and effectiveness of tinnitus activities treatment-online, a self-paced remote counseling program. Am. J. Audiol. 34, 609–620 (2025).
Engelke, M. et al. Pilot study of a smartphone-based tinnitus therapy using structured counseling and sound therapy: a multiple-baseline design with ecological momentary assessment. PLoS Digit. Health 2, e0000183 (2023).
Tyler, R. S., Stocking, C., Ji, H., Witt, S. & Mancini, P. C. Tinnitus activities treatment with total and partial masking. J. Am. Acad. Audiol. 32, 501–509 (2021).
Jastreboff, P. J. & Jastreboff, M. M. Tinnitus retraining therapy (TRT) as a method for treatment of tinnitus and hyperacusis patients. J. Am. Acad. Audiol. 11, 162–177 (2000).
Alashram, A. R. Effects of tinnitus retraining therapy on patients with tinnitus: a systematic review of randomized controlled trials. Eur. Arch. Otorhinolaryngol. 282, 571–587 (2025).
Fuller, T. et al. Cognitive behavioural therapy for tinnitus. Cochrane Database Syst. Rev. 1, CD012614 (2020).
Ueno, M. et al. Effects of hearing aids in patients with unilateral tinnitus with acquired ipsilateral sensorineural hearing loss. Ear Nose Throat J. 104, NP294–NP301 (2025).
Jacquemin, L., Gilles, A. & Shekhawat, G. S. Hearing more to hear less: a scoping review of hearing aids for tinnitus relief. Int. J. Audiol. 61, 887–895 (2022).
Vajsakovic, D., Teng, A. & Searchfield, G. D. A review of auditory rehabilitation uses in hearing aid-based therapy for tinnitus (2013-2024). Semin. Hear. 45, 306–316 (2024).
Hoare, D. J., Edmondson-Jones, M., Sereda, M., Akeroyd, M. A. & Hall, D. Amplification with hearing aids for patients with tinnitus and co-existing hearing loss. Cochrane Database Syst. Rev. 2014, CD010151 (2014).
Joergensen, M. L., Hyvärinen, P., Caporali, S. & Dau, T. Broadband amplification as tinnitus treatment. Brain Sci. 12, 719 (2022).
Levy, D. A. et al. Cochlear implantation for treatment of tinnitus in single-sided deafness: a systematic review and meta-analysis. Otol. Neurotol. 41, e1004–e1012 (2020).
Peter, N., Liyanage, N., Pfiffner, F., Huber, A. & Kleinjung, T. The influence of cochlear implantation on tinnitus in patients with single-sided deafness: a systematic review. Otolaryngol. Head Neck Surg. 161, 576–588 (2019).
Assouly, K. K. S., van Heteren, J. A. A., Stokroos, R. J., Stegeman, I. & Smit, A. L. Cochlear implantation for patients with tinnitus — a systematic review. Prog. Brain Res. 260, 27–50 (2021).
Marinelli, J. P. et al. Electrical stimulation of the cochlea for treatment of chronic disabling tinnitus: an open-label trial towards the development of an implantable device. J. Transl. Med. 20, 56 (2022).
Cavalcante, A. M. G., Silva, I. M. C., Neves, B. J., Oliveira, C. A. & Bahmad, F. Jr. Degree of tinnitus improvement with stapes surgery — a review. Braz. J. Otorhinolaryngol. 84, 514–518 (2018).
Yeh, K.-T., Zhang, B.-Y., Yeh, T.-W. & Chan, K.-C. The impact of tympanoplasty on tinnitus improvement in patients with chronic otitis media: a systematic review and meta-analysis. Ear Nose Throat J. https://doi.org/10.1177/01455613251342954 (2025).
Sereda, M., Xia, J., El Refaie, A., Hall, D. A. & Hoare, D. J. Sound therapy (using amplification devices and/or sound generators) for tinnitus. Cochrane Database Syst. Rev. 12, CD013094 (2018).
Hoare, D. J., Stacey, P. C. & Hall, D. A. The efficacy of auditory perceptual training for tinnitus: a systematic review. Ann. Behav. Med. 40, 313–324 (2010).
Hoare, D. J., Kowalkowski, V. L. & Hall, D. A. Effects of frequency discrimination training on tinnitus: results from two randomised controlled trials. J. Assoc. Res. Otolaryngol. 13, 543–559 (2012).
Teismann, H., Okamoto, H. & Pantev, C. Short and intense tailor-made notched music training against tinnitus: the tinnitus frequency matters. PLoS ONE 6, e24685 (2011).
Davis, P. B., Paki, B. & Hanley, P. J. Neuromonics tinnitus treatment: third clinical trial. Ear Hear. 28, 242–259 (2007).
Tass, P. A., Adamchic, I., Freund, H. J., von Stackelberg, T. & Hauptmann, C. Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restor. Neurol. Neurosci. 30, 137–159 (2012).
Tziridis, K. et al. Phase II clinical study on low-intensity-noise tinnitus suppression (LINTS) for tinnitus treatment. Brain Sci. 15, 1222 (2025).
Langguth, B., Elgoyhen, A. B. & Cederroth, C. R. Therapeutic approaches to the treatment of tinnitus. Annu. Rev. Pharmacol. Toxicol. 59, 291–313 (2019).
Kleinjung, T. & Langguth, B. Pharmacotherapy of tinnitus. Curr. Top. Behav. Neurosci. 51, 193–212 (2021).
Simpson, J. J. & Davies, W. E. Recent advances in the pharmacological treatment of tinnitus. Trends Pharmacol. Sci. 20, 12–18 (1999).
Morin, C. M. et al. Insomnia disorder. Nat. Rev. Dis. Primers 1, 15026 (2015).
Craske, M. G. et al. Anxiety disorders. Nat. Rev. Dis. Primers 3, 17024 (2017).
Marx, W. et al. Major depressive disorder. Nat. Rev. Dis. Primers 9, 44 (2023).
Bhimrao, S. K., Masterson, L. & Baguley, D. Systematic review of management strategies for middle ear myoclonus. Otolaryngol. Head Neck Surg. 146, 698–706 (2012).
Park, J. M., Kim, W. J., Han, J. S., Park, S. Y. & Park, S. N. Management of palatal myoclonic tinnitus based on clinical characteristics: a large case series study. Acta Otolaryngol. 140, 553–557 (2020).
Zhang-Kraczkowska, A. & Wong, W. K. Middle ear myoclonus: pathophysiology and management. Curr. Opin. Otolaryngol. Head Neck Surg. 33, 281–285 (2025).
Narsinh, K. H., Hui, F., Duvvuri, M., Meisel, K. & Amans, M. R. Management of vascular causes of pulsatile tinnitus. J. Neurointerv. Surg. 14, 1151–1157 (2022).
Sathya, A. et al. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: a systematic review. Interv. Neuroradiol. https://doi.org/10.1177/15910199241231325 (2024).
Levine, R. A. Typewriter tinnitus: a carbamazepine-responsive syndrome related to auditory nerve vascular compression. ORL 68, 43–46 (2006).
van den Berge, M. J. C. et al. Microvascular decompression of the cochleovestibular nerve for treatment of tinnitus and vertigo: a systematic review and meta-analysis of individual patient data. J. Neurosurg. 127, 588–601 (2017).
Güntensperger, D., Thüring, C., Meyer, M., Neff, P. & Kleinjung, T. Neurofeedback for tinnitus treatment — review and current concepts. Front. Aging Neurosci. 9, 386 (2017).
Lefebvre-Demers, M., Doyon, N. & Fecteau, S. Non-invasive neuromodulation for tinnitus: a meta-analysis and modeling studies. Brain Stimul. 14, 113–128 (2021).
Deklerck, A. N. et al. Invasive neuromodulation as a treatment for tinnitus: a systematic review. Neuromodulation 23, 451–462 (2020).
De Ridder, D., Adhia, D. & Langguth, B. Tinnitus and brain stimulation. Curr. Top. Behav. Neurosci. 51, 249–293 (2021).
Conlon, B. et al. Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial. Sci. Rep. 12, 10845 (2022).
Jones, G. R. et al. Reversing synchronized brain circuits using targeted auditory-somatosensory stimulation to treat phantom percepts: a randomized clinical trial. JAMA Netw. Open 6, e2315914 (2023).
Tyler, R. et al. Vagus nerve stimulation paired with tones for the treatment of tinnitus: a prospective randomized double-blind controlled pilot study in humans. Sci. Rep. 7, 11960 (2017).
Boedts, M. et al. Combining sound with tongue stimulation for the treatment of tinnitus: a multi-site single-arm controlled pivotal trial. Nat. Commun. 15, 6806 (2024). This paper reports a multi-site pivotal clinical trial showing that bimodal neuromodulation produces clinically meaningful improvements beyond sound-only stimulation, especially in patients with moderate-or-worse tinnitus, with no device-related serious adverse events, supporting its FDA de novo authorization.
Hall, D. A. et al. A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Health Qual. Life Outcomes 16, 61 (2018).
Ware, J. E. & Gandek, B. The SF-36 health survey: development and use in mental health research and the IQOLA project. Int. J. Ment. Health 23, 49–73 (1994).
Ware, J. E. et al. User’s Manual for the SF-36v2 Health Survey (QualityMetric Incorporated, 2007).
Diener, E., Emmons, R. A., Larsen, R. J. & Griffin, S. The satisfaction with life scale. J. Pers. Assess. 49, 71–75 (1985).
Daoud, E., Caimino, C., Akeroyd, M. A., Norena, A. J. & Baguley, D. M. The utility of economic measures to quantify the burden of tinnitus in affected individuals: a scoping review. Pharmacoecon. Open 6, 21–32 (2022).
Trochidis, I. et al. Systematic review on healthcare and societal costs of tinnitus. Int. J. Env. Res. Public Health 18, 6881 (2021).
Goldstein, E. et al. Cost of care for subjective tinnitus in relation to patient satisfaction. Otolaryngol. Head Neck Surg. 152, 518–523 (2015).
Newman, C. W. & Sandridge, S. A. A comparison of benefit and economic value between two sound therapy tinnitus management options. J. Am. Acad. Audiol. 23, 126–138 (2012).
Maes, I. H., Cima, R. F., Vlaeyen, J. W., Anteunis, L. J. & Joore, M. A. Tinnitus: a cost study. Ear Hear. 34, 508–514 (2013).
Maes, I. H. et al. Cost-effectiveness of specialized treatment based on cognitive behavioral therapy versus usual care for tinnitus. Otol. Neurotol. 35, 787–795 (2014).
Stockdale, D. et al. An economic evaluation of the healthcare cost of tinnitus management in the UK. BMC Health Serv. Res. 17, 577 (2017).
Tziridis, K., Friedrich, J., Brueggemann, P., Mazurek, B. & Schulze, H. Estimation of tinnitus-related socioeconomic costs in Germany. Int. J. Env. Res. Public Health 19, 10455 (2022).
Jarach, C. M. et al. The out-of-pocket expenses of people with tinnitus in Europe. J. Epidemiol. 34, 515–525 (2024).
Carlson, K. F. et al. Health care utilization and mental health diagnoses among veterans with Tinnitus. Am. J. Audiol. 28, 181–190 (2019).
Mancini, P. C. et al. Tinnitus: how partners can help? Am. J. Audiol. 28, 85–94 (2019).
Beukes, E. W., Ulep, A. J., Andersson, G. & Manchaiah, V. The effects of tinnitus on significant others. J. Clin. Med. 11, 1393 (2022).
Borre, E. D. et al. The impact of hearing loss and its treatment on health-related quality of life utility: a systematic review with meta-analysis. J. Gen. Intern. Med. 38, 456–479 (2023).
Coco, L. et al. The impact of tinnitus severity on work functioning among U.S. military veterans with tinnitus. Semin. Hear. 45, 40–54 (2024).
Fagelson, M. A. & Smith, S. L. Tinnitus self-efficacy and other tinnitus self-report variables in patients with and without post-traumatic stress disorder. Ear Hear. 37, 541–546 (2016).
Mazurek, B., Böcking, B., Dobel, C., Rose, M. & Brüggemann, P. Tinnitus and influencing comorbidities. Laryngorhinootologie 102, S50–S58 (2023).
Martinez-Devesa, P., Perera, R., Theodoulou, M. & Waddell, A. Cognitive behavioural therapy for tinnitus. Cochrane Database Syst. Rev. 2010, CD005233 (2010).
Landry, E. C. et al. Systematic review and network meta-analysis of cognitive and/or behavioral therapies (CBT) for tinnitus. Otol. Neurotol. 41, 153–166 (2020).
Langguth, B., Kleinjung, T., Schlee, W., Vanneste, S. & De Ridder, D. Tinnitus guidelines and their evidence base. J. Clin. Med. 12, 3087 (2023).
Shabestari, P. S. et al. Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach. Sci. Rep. 15, 10968 (2025).
Mohan, A., Luckey, A., Weisz, N. & Vanneste, S. Predisposition to domain-wide maladaptive changes in predictive coding in auditory phantom perception. Neuroimage 248, 118813 (2022).
Weisz, N., Wienbruch, C., Dohrmann, K. & Elbert, T. Neuromagnetic indicators of auditory cortical reorganization of tinnitus. Brain 128, 2722–2731 (2005).
Smith, S. S., Jahn, K. N., Sugai, J. A., Hancock, K. E. & Polley, D. B. Objective autonomic signatures of tinnitus and sound sensitivity disorders. Sci. Transl. Med. 17, eadp1934 (2025).
Fournier, P. & Hebert, S. Gap detection deficits in humans with tinnitus as assessed with the acoustic startle paradigm: does tinnitus fill in the gap? Hear. Res. 295, 16–23 (2013).
Shabestari, P. S. et al. Inhibition of cortical evoked responses to sound pulses by preceding silent gaps. J. Assoc. Res. Otolaryngol. 26, 515–529 (2025).
Turner, J. G. et al. Gap detection deficits in rats with tinnitus: a potential novel screening tool. Behav. Neurosci. 120, 188–195 (2006).
Wang, H. et al. Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results. Nat. Med. 30, 1898–1904 (2024).
Valayannopoulos, V. et al. DB-OTO gene therapy for inherited deafness. N. Engl. J. Med. 394, 1074–1083 (2025).
Li, Z., Zhang, Y., Xiao, Z. & Qi, J. The reconstruction of peripheral auditory circuit: recent advances and future challenges. Adv. Sci. 12, e2410494 (2025).
Huang, Y. et al. Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors. Cell Prolif. 58, e13775 (2025).
Bastille, I. et al. Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons. Cell Rep. 44, 115796 (2025).
Hyde, J. et al. Efficacy of neurostimulation across mental disorders: systematic review and meta-analysis of 208 randomized controlled trials. Mol. Psychiatry 27, 2709–2719 (2022).
Rektorová, I., Pupíková, M., Fleury, L., Brabenec, L. & Hummel, F. C. Non-invasive brain stimulation: current and future applications in neurology. Nat. Rev. Neurol. 21, 669–686 (2025).
Vanneste, S. & Langguth, B. in Textbook of Tinnitus (eds Schlee, W. et al.) 667–678 (Springer, 2024).
Vanneste, S. & Kleinjung, T. in Textbook of Tinnitus (eds Schlee, W. et al.) 653–666 (Springer, 2024).
Van Hoornweder, S., Stagg, C. J. & Wischnewski, M. Personalizing transcranial electrical stimulation. Trends Neurosci. 48, 663–678 (2025).
Soleimani, G. et al. Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments. Transl. Psychiatry 13, 279 (2023).
Riddle, J. & Frohlich, F. Targeting neural oscillations with transcranial alternating current stimulation. Brain Res. 1765, 147491 (2021).
Vanneste, S., Reynolds, J. & De Ridder, D. Focused transcranial ultrasound stimulation: a breakthrough approach to treating brain disorders. Expert Rev. Med. Devices 22, 1231–1242 (2025).
Smit, J. V. et al. Deep brain stimulation in tinnitus: current and future perspectives. Brain Res. 1608, 51–65 (2015).
Lozano, A. M. et al. Deep brain stimulation: current challenges and future directions. Nat. Rev. Neurol. 15, 148–160 (2019).
Langguth, B., Elgoyhen, A. B. & Schlee, W. Potassium channels as promising new targets for pharmacologic treatment of tinnitus: can internet-based ‘crowd sensing’ initiated by patients speed up the transition from bench to bedside? Expert Opin. Ther. Targets 20, 251–254 (2016).
Mehdi, M., Hauck, F. J., Pryss, R. & Schlee, W. in Textbook of Tinnitus (eds Schlee, W. et al.) 731–738 (Springer, 2024).
Michiels, S., Wölflick, S., Simões, J. & Schlee, W. Exploring app-based physiotherapy for somatic tinnitus: results from a pilot study. J. Clin. Med. 13, 7203 (2024).
Wagenaar, O., Gilles, A., Jacquemin, L., Van Rompaey, V. & Blom, H. Tinnitus management by improving resilience using exposure in virtual reality: a scoping review. Eur. Arch. Otorhinolaryngol. 282, 4997–5004 (2025).
Walter, U. et al. Randomized controlled trial of a smartphone-based cognitive behavioral therapy for chronic tinnitus. PLoS Digit. Health 2, e0000337 (2023).
Schoisswohl, S. et al. Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial. Nat. Commun. 16, 10510 (2025).
National Institute for Health and Care Excellence. Tinnitus: assessment and management. NICE https://www.nice.org.uk/guidance/NG155 (2020).
Mazurek, B. et al. Guideline group. Chronic tinnitus. Dtsch. Arztebl. Int. 119, 219–225 (2022).
Yuen, E., Ma, C., Nguyen, S. A., Meyer, T. A. & Lambert, P. R. The effect of cochlear implantation on tinnitus and quality of life: a systematic review and meta-analysis. Otol. Neurol. 42, 1113–1122 (2021).
Hoekstra, C. E., Rynja, S. P., van Zanten, G. A. & Rovers, M. M. Anticonvulsants for tinnitus. Cochrane Database Syst. Rev. 2011, CD007960 (2011).
Baldo, P., Doree, C., Molin, P., McFerran, D. & Cecco, S. Antidepressants for patients with tinnitus. Cochrane Database Syst. Rev. 2012, CD003853 (2012).
Wegner, I., Hall, D. A., Smit, A. L., McFerran, D. & Stegeman, I. Betahistine for tinnitus. Cochrane Database Syst. Rev. 12, CD013093 (2018).
Sereda, M. et al. Ginkgo biloba for tinnitus. Cochrane Database Syst. Rev. 11, CD013514 (2022).
Han, M., Yang, X. & Lv, J. Efficacy of tinnitus retraining therapy in the treatment of tinnitus: a meta-analysis and systematic review. Am. J. Otolaryngol. 42, 103151 (2021).
Martins, M. L. et al. Effect of transcranial direct current stimulation for tinnitus treatment: a systematic review and meta-analysis. Neurophysiol. Clin. 52, 1–16 (2022).
Yin, L. et al. An updated meta-analysis: repetitive transcranial magnetic stimulation for treating tinnitus. J. Int. Med. Res. 49, 300060521999549 (2021).