Meal timing and eating window with all-cause and cardiovascular mortality and life expectancy: population-based cohort study

Shan, Zhilei · Nature

8 min read Original article ↗

References

  1. Reinke H, Asher G. Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol. 2019;20:227–41.

    Article  CAS  PubMed  Google Scholar 

  2. Longo VD, Panda S. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metab. 2016;23:1048–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kant AK, Graubard BI. 40-year trends in meal and snack eating behaviors of American adults. J Acad Nutr Diet. 2015;115:50–63.

    Article  PubMed  Google Scholar 

  4. Farsijani S, Mao Z, Cauley JA, Newman AB. Comprehensive assessment of chrononutrition behaviors among nationally representative adults: insights from National Health and Nutrition Examination Survey (NHANES) data. Clin Nutr. 2023;42:1910–21.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Challet E. The circadian regulation of food intake. Nat Rev Endocrinol. 2019;15:393–405.

    Article  PubMed  Google Scholar 

  6. Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Melatonin effects on glucose metabolism: time to unlock the controversy. Trends Endocrinol Metab. 2020;31:192–204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chen H, Zhang B, Ge Y, Shi H, Song S, Xue W, et al. Association between skipping breakfast and risk of cardiovascular disease and all-cause mortality: a meta-analysis. Clin Nutr. 2020;39:2982–8.

    Article  PubMed  Google Scholar 

  8. Sun Y, Rong S, Liu B, Du Y, Wu Y, Chen L, et al. Meal skipping and shorter meal intervals are associated with increased risk of all-cause and cardiovascular disease mortality among US adults. J Acad Nutr Diet. 2023;123:417–426.e3.

    Article  PubMed  Google Scholar 

  9. Kant AK, Graubard BI. Clock time of first eating episode and prospective risk of all-cause mortality in US adults. J Nutr. 2022;152:217–26.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Wang P, Tan Q, Zhao Y, Zhao J, Zhang Y, Shi D. Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from National Health and Nutrition Examination Survey. Nutr Diab. 2024;14:5.

    Article  CAS  Google Scholar 

  11. Manoogian ENC, Zadourian A, Lo HC, Gutierrez NR, Shoghi A, Rosander A, et al. Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: the healthy heroes randomized control trial. Cell Metab. 2022;34:1442–1456.e7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Li C, Xing C, Zhang J, Zhao H, Shi W, He B. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. J Transl Med. 2021;19:148.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Dawson MA, Cheung SN, La Frano MR, Nagpal R, Berryman CE. Early time-restricted eating improves markers of cardiometabolic health but has no impact on intestinal nutrient absorption in healthy adults. Cell Rep Med. 2024;5:101363.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Chudasama YV, Khunti K, Gillies CL, Dhalwani NN, Davies MJ, Yates T, et al. Estimates of years of life lost depended on the method used: tutorial and comparative investigation. J Clin Epidemiol. 2022;150:42–50.

    Article  PubMed  Google Scholar 

  15. Chen T-C, Clark J, Riddles MK, Mohadjer LK, Fakhouri THI. National health and nutrition examination survey, 2015–2018: sample design and estimation procedures. Vital Health Stat 2. 2020;184:1–35.

    Google Scholar 

  16. Gill S, Panda S. A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell Metab. 2015;22:789–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Shams-White MM, Pannucci TE, Lerman JL, Herrick KA, Zimmer M, Meyers Mathieu K, et al. Healthy eating index-2020: review and update process to reflect the dietary guidelines for Americans, 2020–2025. J Acad Nutr Diet. 2023;123:1280–8.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Smith KJ, Gall SL, McNaughton SA, Blizzard L, Dwyer T, Venn AJ. Skipping breakfast: longitudinal associations with cardiometabolic risk factors in the childhood determinants of adult health study. Am J Clin Nutr. 2010;92:1316–25.

    Article  CAS  PubMed  Google Scholar 

  19. Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, et al. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018;138:345–55.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Rong S, Snetselaar LG, Xu G, Sun Y, Liu B, Wallace RB, et al. Association of skipping breakfast with cardiovascular and all-cause mortality. J Am Coll Cardiol. 2019;73:2025–32.

    Article  PubMed  Google Scholar 

  21. Pons-Muzzo L, de Cid R, Obón-Santacana M, Straif K, Papantoniou K, Santonja I, et al. Sex-specific chrono-nutritional patterns and association with body weight in a general population in Spain (GCAT study). Int J Behav Nutr Phys Act. 2024;21:102.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Walton K, Horton NJ, Rifas-Shiman SL, Field AE, Austin SB, Haycraft E, et al. Exploring the role of family functioning in the association between frequency of family dinners and dietary intake among adolescents and young adults. JAMA Netw Open. 2018;1:e185217.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Blake CE, Wethington E, Farrell TJ, Bisogni CA, Devine CM. Behavioral contexts, food-choice coping strategies, and dietary quality of a multiethnic sample of employed parents. J Am Diet Assoc. 2011;111:401–7.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Rahman MO. Age and gender variation in the impact of household structure on elderly mortality. Int J Epidemiol. 1999;28:485–91.

    Article  CAS  PubMed  Google Scholar 

  25. Gu F, Han J, Laden F, Pan A, Caporaso NE, Stampfer MJ, et al. Total and cause-specific mortality of U.S. nurses working rotating night shifts. Am J Prev Med. 2015;48:241–52.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Liu J, Yi P, Liu F. The effect of early time-restricted eating vs later time-restricted eating on weight loss and metabolic health. J Clin Endocrinol Metab. 2023;108:1824–34.

    Article  CAS  PubMed  Google Scholar 

  27. Xie Z, Sun Y, Ye Y, Hu D, Zhang H, He Z, et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun. 2022;13:1003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Manoogian ENC, Chow LS, Taub PR, Laferrère B, Panda S. Time-restricted Eating for the Prevention and Management of Metabolic Diseases. Endocr Rev. 2022;43:405–36.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Semnani-Azad Z, Khan TA, Chiavaroli L, Chen V, Bhatt HA, Chen A, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389:e082007.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Parr EB, Kouw IWK, Wheeler MJ, Radford BE, Hall RC, Senden JM, et al. Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: a randomized controlled trial. Obesity. 2023;31:116–26.

    Article  CAS  PubMed  Google Scholar 

  31. Li L, Li R, Tian Q, Luo Y, Li R, Lin X, et al. Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: feeding RCT. Cell Rep Med. 2024;5:101801.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Wang N, Xiao Y, Zhang W, Doherty M, Zhang Y, Xie J, et al. Sarcopenia and risk of cardiovascular events and mortality: a meta-analysis of longitudinal observational studies. Can J Cardiol. 2026. https://doi.org/10.1016/j.cjca.2026.02.054

  33. Mao Z, Cawthon PM, Kritchevsky SB, Toledo FGS, Esser KA, Erickson ML, et al. The association between chrononutrition behaviors and muscle health among older adults: the study of muscle, mobility and aging. Aging Cell. 2023;23:e14059.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Estrada-de León DB, Struijk EA, Caballero FF, Ortolá R, Guallar-Castillón P, Banegas JR, et al. Association of prolonged nightly fasting with cardiovascular, renal, inflammation, and nutritional status biomarkers in community-dwelling older adults. Am J Clin Nutr. 2022;115:1282–9.

    Article  PubMed  Google Scholar 

  35. Cheng W, Meng X, Gao J, Jiang W, Sun X, Li Y, et al. Relationship between circadian eating behavior (daily eating frequency and nighttime fasting duration) and cardiovascular mortality. Int J Behav Nutr Phys Act. 2024;21:22.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Ma H, Wang X, Xue Q, Li X, Liang Z, Heianza Y, et al. Cardiovascular health and life expectancy among adults in the United States. Circulation. 2023;147:1137–46.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Lewis P, Oster H, Korf HW, Foster RG, Erren TC. Food as a circadian time cue - evidence from human studies. Nat Rev Endocrinol. 2020;16:213–23.

    Article  PubMed  Google Scholar 

  38. Shimizu H, Hanzawa F, Kim D, Sun S, Laurent T, Umeki M, et al. Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet. PLoS One. 2018;13:e0206669.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Kim D, Hanzawa F, Sun S, Laurent T, Ikeda S, Umeki M, et al. Delayed meal timing, a breakfast skipping model, increased hepatic lipid accumulation and adipose tissue weight by disintegrating circadian oscillation in rats fed a high-cholesterol diet. Front Nutr. 2021;8:681436.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ni Y, Wu L, Jiang J, Yang T, Wang Z, Ma L, et al. Late-night eating-induced physiological dysregulation and circadian misalignment are accompanied by microbial dysbiosis. Mol Nutr Food Res. 2019;63:1900867.

    Article  CAS  Google Scholar 

  41. Zhang J, Tian R, Liu J, Yuan J, Zhang S, Chi Z, et al. A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense. Cell. 2024;187:6251–71.

    Article  CAS  PubMed  Google Scholar 

  42. Fischer D, Lombardi DA, Marucci-Wellman H, Roenneberg T. Chronotypes in the US - influence of age and sex. PLoS One. 2017;12:e0178782.

    Article  PubMed  PubMed Central  Google Scholar 

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