- COMMENT
Biomedical research techniques that don’t involve the use of animals are gaining momentum, but those using innovative approaches still face resistance from some quarters.
By
- Anke Brüning-Richardson1,
- Julie E. Gough2,
- Aline F. Miller3,
- Geoffrey J. Pilkington4,
- John Greenman5,
- Valerie Speirs6 &
- …
- Joseph C. Wu7
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Todd J. Herron
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Todd J. Herron is a director at Greenstone Biosciences, Palo Alto, California, USA.
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Anke Brüning-Richardson
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Anke Brüning-Richardson is a senior lecturer in the School of Applied Sciences, University of Huddersfield, UK.
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Julie E. Gough
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Julie E. Gough is professor of biomaterials and tissue engineering in the Department of Materials, School of Natural Sciences and NIHR Manchester Biomedical Research Centre, University of Manchester, UK.
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Aline F. Miller
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Aline F. Miller is professor of biomolecular engineering in the Department of Chemical Engineering and Manchester Institute of Biotechnology, University of Manchester, UK.
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Geoffrey J. Pilkington
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Geoffrey J. Pilkington is emeritus professor of cellular and molecular neuro-oncology at the Brain Tumour Research Centre, University of Portsmouth, UK.
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John Greenman
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John Greenman is professor of tumour immunology at the Centre for Biomedicine, Hull York Medical School, University of Hull, UK.
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Valerie Speirs
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Valerie Speirs is professor of molecular oncology in the School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
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Joseph C. Wu
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Joseph C. Wu is director of the Stanford Cardiovascular Institute and professor of medicine and radiology at Stanford University School of Medicine, California, USA.
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When it comes to evaluating drugs or understanding basic biology, researchers are increasingly favouring various innovative experimental approaches over animal models or immortalized human cell lines.
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Nature 646, 799-801 (2025)
doi: https://doi.org/10.1038/d41586-025-03344-6
References
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Yildirim, Z., Swanson, K., Wu, X., Zou, J. & Wu, J. Annu. Rev. Pharmacol. Toxicol. 65, 71–90 (2025).
Yang, L. et al. Int. J. Cardiol. 363, 149–158 (2022).
Lee, J. et al. Nature 572, 335–340 (2019).
Sayed, N. et al. Sci. Transl. Med. 12, eaax9276 (2020).
Mukherjee, S. et al. Circulation 151, 285–287 (2025).
Husain, A., Meenakshi, D. U., Ahmad, A., Shrivastava, N. & Khan, S. A. J. Pharm. Bioallied Sci. 15, 165–171 (2023).
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Krebs, C. E., Lam, A., McCarthy, J., Constantino, H. & Sullivan, K. ALTEX 40, 665–676 (2023).
Blinova, K. et al. Cell Rep. 24, 3582–3592 (2018).
Gintant, G. et al. Regul. Toxicol. Pharmacol. 117, 104756 (2020).
Competing Interests
J.C.W. is a co-founder and scientific advisory board member of Greenstone Biosciences.
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