- RESEARCH BRIEFINGS
The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mechanism that underlies this unexpected role of lactate in cancer.
This is a summary of: Chen, H. et al. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature 631, 663–669 (2024).
doi: https://doi.org/10.1038/d41586-024-02731-9
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Read the paper: NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
