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Prion diseases are caused by misfolded proteins, but a new tool can stop them forming in mice.
A molecular-editing tool that’s small enough to be delivered to the brain shuts down the production of proteins that cause prion diseases, a rare but deadly group of neurodegenerative disorders.
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doi: https://doi.org/10.1038/d41586-024-02115-z
References
Neumann, E. N. et al. Science 384, eado7082 (2024).
Raymond, G. J. et al. JCI Insight 5, e131175 (2019).
Nuñez, J. K. et al. Cell 184, 2503–2519 (2021).
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