The future of precision cancer therapy might be to try everything

3 min read Original article ↗

Researchers are blasting patients’ cancer cells with dozens of drugs in the hope of finding the right treatment.

By

  1. Elie Dolgin
    1. Elie Dolgin is a science journalist in Somerville, Massachusetts.

Cartoon showing various pills, tablets and syringes flying towards a tumour cell with one syringe piercing it.

Illustration: Shira Inbar

The blood cancer had returned, and Kevin Sander was running out of treatment options. A stem-cell transplant would offer the best chance for long-term survival, but to qualify for the procedure he would first need to reduce the extent of his tumour — a seemingly insurmountable goal, because successive treatments had all failed to keep the disease in check.

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

$32.99 / 30 days

cancel any time

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Nature 626, 470-473 (2024)

doi: https://doi.org/10.1038/d41586-024-00392-2

Updates & Corrections

  • Correction 15 February 2024: An earlier version of this feature stated that Philipp Staber’s lab uses a 386-well plate.

References

  1. Kornauth, C. et al. Cancer Discov. 12, 372–387 (2022).

    Article  PubMed  Google Scholar 

  2. Snijder, B. et al. Lancet Haematol. 4, e595–e606 (2017).

    Article  PubMed  Google Scholar 

  3. O’Dwyer, P. J. et al. Nature Med. 29, 1349–1357 (2023).

    Article  PubMed  Google Scholar 

  4. Malani, D. et al. Cancer Discov. 12, 388–401 (2022).

    Article  PubMed  Google Scholar 

  5. Ranjan, T. et al. Cell Rep. Med. 4, 101025 (2023).

    Article  PubMed  Google Scholar 

  6. Ranjan, T. et al. Neurooncol Adv. 5, vdad055 (2023).

    PubMed  Google Scholar 

  7. Manzano-Muñoz, A. et al. npj Precis. Oncol. 6, 90 (2022).

    Article  PubMed  Google Scholar 

  8. Mayoh, C. et al. Cancer Res. 83, 2716–2732 (2023).

    Article  PubMed  Google Scholar 

  9. Al-Aloosi, M. et al. Front. Oncol. 13, 1267650 (2024).

    Article  PubMed  Google Scholar 

  10. Gray, H. J. et al. npj Precis. Oncol. 7, 45 (2023).

    Article  PubMed  Google Scholar 

  11. Bangi, E. et al. iScience 24, 102212 (2021).

    Article  PubMed  Google Scholar 

  12. Bangi, E. et al. Sci. Adv. 5, eaav6528 (2019).

    Article  PubMed  Google Scholar 

  13. Tsai, L. L. et al. Ann. Surg. 277, e1143–e1149 (2023).

    Article  PubMed  Google Scholar 

  14. Peruzzi, P. et al. Sci. Transl. Med. 15, eadi0069 (2023).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on: