Omicron-targeted vaccines do no better than original jabs in early tests

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Experiments in animals show that boosters customized for the fast-spreading COVID variant offer little advantage over standard jabs.

By

  1. Emily Waltz

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As the Omicron variant of SARS-CoV-2 continues its global rampage, vaccine makers are pouring resources into clinical trials of COVID-19 shots tailored to the highly transmissible variant. But a raft of early animal studies suggest that Omicron-specific boosters offer no advantage over a third dose of current vaccines1–4.

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doi: https://doi.org/10.1038/d41586-022-00003-y

References

  1. Gagne, M. et al. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/2022.02.03.479037v1?s=08 (2022).

  2. Ying, B. et al. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/2022.02.07.479419v1 (2022).

  3. Lee, I.-J. et al. Preprint at bioRixv https://www.biorxiv.org/content/10.1101/2022.01.31.478406v1 (2022).

  4. Hawman, D. W. et al. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/2022.01.31.478520v1 (2022).

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