Differential Diagnosis Calculations
ANI: 000
ALD/NAFLD Index is used for distinguishing Alcoholic from Nonalcoholic Fatty Liver Disease.
To calculate ANI, enter values for: Gender, Weight, Height, AST, ALT, MCV.
- < -2.2 - NAFLD
- -2.2 - 2.2 - Mixed
- > 2.2 - ALD
Probability of Alcoholic Liver Disease:
000%
ANI is useful if patient's alcohol consumption history is unclear or deemed unreliable. Short-term abstinence (few months) does not significantly alter the ANI.
It is crucial to exclude other potential causes of liver disease before applying the ANI.
R-Factor: 000
R-Factor is used for distinguishing acute liver injury (Hepatocellular from Cholestatic). Often used when drug induced liver injury (DILI) is suspected.
- < 2 - Cholestatic
- 2 - 5 - Mixed
- > 5 - Hepatocellular
To calculate R-Factor, enter values for: ALT, ALP.
R-Factor is optimal
D/T Bilirubin Ratio: 000 mg/mg
The D/T ratio is used to differentiate between different types of jaundice and liver injury patterns.
- < 0.2 - Pre-hepatic
- 0.2 - 0.5 - Hepatocellular
- > 0.5 - Cholestatic
To calculate D/T Bilirubin Ratio, enter values for: Bilirubin (Total), Bilirubin (Direct).
D/T Bilirubin Ratio is optimal
Hepatic steatosis | Fatty liver disease | NAFLD | NASH
TyG-BMI: 000
Triglyceride-Glucose index multiplied by BMI is one of the best models to predict NAFLD.
To calculate TyG-BMI, enter values for: Weight, Height, Triglycerides, Glucose.
- yellow - NAFLD possible
- red - NAFLD likely
FLI: 000
Fatty Liver Index is one of the best models to predict liver fat content.
To calculate FLI, enter values for: Weight, Height, Waist circumference, Triglycerides, GGT.
Gender is required to interpret FLI.
- yellow - Fatty liver possible
- red - Fatty liver likely
Hepatic fibrosis | Liver scarring
FIB-3: 000
The Fibrosis-3 Index is an improved version of the FIB-4, that does not include age. It outperforms both FIB-4 and APRI.
To calculate FIB-3, enter values for: AST, ALT, PLT.
- yellow - F2 or higher fibrosis possible
- red - F3 or higher fibrosis possible
LSS: 000
Liver stiffness score is currently one of the best models to predict liver fibrosis. Outperforms FIB-4, APRI and HSI. Trained on NHANES dataset.
To calculate LSS, enter values for: Weight, AST, PLT, Albumin, History of diabetes.
- yellow - F2 or higher fibrosis possible
- red - F2 or higher fibrosis likely
Probabilities of having different fibrosis stages:
Stage F2 fibrosis is fully reversible, Stage F3 is partially reversible, and Stage F4 is largely irreversible.
Individual biomarkers
Plots show optimal ranges; values above the ULN are displayed as multiples (×
ULN), values below the LLN as percentage (% of
LLN).
AST: 000 IU/L
Transaminase released from hepatocytes and cardiac/skeletal muscle (with minor contributions from kidney, pancreas, brain, RBCs and gallbladder).
Enter value for AST to interpret.
AST is optimal
ALT: 000 IU/L
Highly liver-specific transaminase, but with minor contributions from skeletal and cardiac muscle, pancreas, and gut.
Enter value for ALT to interpret.
ALT is optimal
ALP: 000 IU/L
Alkaline phosphatase is primarily released from the bile ducts and bone. Minor sources include the intestinal mucosa, kidneys, and placental tissue (during pregnancy).
Enter value for ALP to interpret.
ALP is optimal
GGT: 000 IU/L
Serum Gamma-glutamyl transferase usually originates from hepatocytes and cholangiocytes (plus pancreas).
Enter value for GGT to interpret.
GGT is optimal
Bilirubin (Total): 000 mg/dL
Heme-catabolism end-product processed by the liver and excreted in bile, reflecting hemolysis and hepatic clearance.
Enter value for Bilirubin (Total) to interpret.
Bilirubin (Total) is optimal
Albumin: 000 g/dL
Principal liver-synthesized plasma protein maintaining oncotic pressure and ferrying hormones, drugs and nutrients.
Enter value for Albumin to interpret.
Albumin is optimal