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Glucose Metabolism InterpreterProvides a comprehensive metabolic assessment of blood glucose control and helps distinguish between common glucose metabolism disorders, including type 1, type 2, and type 3 diabetes, pre-diabetes, insulin resistance.
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Measure glucose and insulin from plasma
This tool is for informational purposes only and not intended for diagnosis.
Patient Adherence Checks
The patient needs to be fasted for 10 to 15 hours and not on insulin for this interpretation to work.
Exogenous Insulin Status Unknown
Enter C-peptide and Insulin
Diagnosis Summary
Based on standard diagnostic criteria. Diagnosis requires two abnormal screening test results. Only your doctor can make a formal diagnosis.
| Condition | Status |
|---|---|
| Insulin resistance | Unknown |
| Pre-diabetes | Unknown |
| Diabetes | Unknown |
Interpretation details
HOMA2 Insulin Resistance: 000
HOMA2-IR provides the best estimate of the gold-standard insulin sensitivity test: euglycemic clamp.
How effectively your body uses insulin:
- 0.4 - 0.6 - Too sensitive (malnutrition, marathon runners...)
- 1.2 - 1.7 - Insulin resistance
- 1.7 - 2.7 - Pre-diabetes likely
- > 2.7 - Diabetes likely
HOMA2 Beta Cell Function: 000%
HOMA2-%B provides a good estimate of the gold-standard insulin secretion test: hyperglycemic clamp.
How effectively your pancreas produces insulin to manage blood sugar (given as a percentage of expected output).
- Elevated/High (or even normal) during early insulin resistance, when the pancreas can still compensate.
- Decreased once the pancreas fails to compensate (late stage).
LDH: 000 IU/L
Lactate dehydrogenase is an intracellular enzyme released into the blood from damaged or stressed cells, most abundantly from muscle, liver, heart, kidneys, lungs, and red blood cells.
LDH is non-specific and can be elevated by intense exercise, muscle injury, or hemolysis, tumor etc. However, in the context of metabolic syndrome:
Triglycerides: 000 mg/dL
Triglycerides are blood fats formed from extra calories; high levels flag metabolic syndrome.
Body converts excess glucose into triglycerides.
- Elevated Triglycerides is seen in insulin resistance and pre-diabetes.
- High Triglycerides is seen in diabetes.
- Low Triglycerides is seen in low carbohydrate intake / calorie deficit.
C-peptide/insulin: 000
C-peptide to insulin molar ratio is helpful in detecting exogenous insulin use, impaired hepatic insulin clearance and impaired C-peptide clearance by the kidneys.
To calculate C-peptide/insulin, enter values for: C-peptide, Insulin.
Decreased c-peptide to insulin ratio is seen in states of reduced hepatic insulin extraction and severe obesity.
Low ratio is seen in exogenous insulin intake and in rare insulin-receptor/mutant-insulin syndromes.
Mixed pattern / inconclusive
High c-peptide to insulin ratio is most often seen when renal clearance of C-peptide is reduced (e.g., chronic kidney disease).
C-peptide/insulin
is optimal
Glucose: 000 mg/dL
Fasting Glucose
Enter value for Glucose to interpret.
QUICKI: 000
QUICKI correlates well (r = 0.78) with the gold standard - Glucose clamp index of insulin sensitivity
To calculate QUICKI, enter values for: Glucose, Insulin.
- < 0.3 - Diabetes
- 0.3 - 0.34 - Insulin res.
HOMA-IR: 000
HOMA1-IR has a poor correlation (r = -0.60) with the gold standard - Glucose clamp index of insulin sensitivity.
To calculate HOMA-IR, enter values for: Glucose, Insulin.
Do not use this (HOMA-IR).
HOMA-IR is frequently reported on laboratory results, but it is relatively imprecise. It is included solely for familiarity. But for accurate assessment, rely on a much better HOMA2-IR or QUICKI.
Non-insulin dependent indexes
TyG: 000
Triglyceride-glucose index is an inexpensive non-insulin surrogate marker of insulin resistance.
To calculate TyG, enter values for: Triglycerides, Glucose.
Triglyceride/HDL: 000
Triglyceride-to-HDL ratio is a surrogate marker of insulin resistance, NAFLD and atherogenic dyslipidemia.
To calculate Triglyceride/HDL, enter values for: Triglycerides, HDL.
Why this beats ChatGPT
All research is done by humans. AI was only used to refine the writing for better readability.
Optimal ranges, not just “normal”
Generic AI uses normal lab ranges (based on population averages). This tool uses functional, best-outcome targets.
Evidence-locked math. Not hallucinations
Generic AI chatbots don’t know which calculated indices are best or their optimal cutoff values.
Clinically significant differentials
We run relevant differential diagnosis calculations, but only when it's clinically significant.
Privacy by default
Everything happens in your browser and no personal or medical information leaves your computer.
About the site author
My personal mission is to extend human lifespan by collectively adding 1 million years to people's lives.
That’s why I made this site 100% free—no sign-up, no email. Just instant results.
Zsolt Szabo
Precision Health Consultant for Longevity Clinics, Biohacker, and Software Engineer
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