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Abstract
The invention relates to a traditional Chinese medicine composition, and particularly discloses a prescription for treating pneumonia caused by novel coronavirus infection and application thereof. The raw materials of the prescription comprise the following traditional Chinese medicine materials in parts by weight: 9 parts of ephedra, 6 parts of honey-fried licorice root, 9 parts of almond, 15-30 parts of gypsum, 9 parts of cassia twig, 9 parts of rhizoma alismatis, 9 parts of grifola, 9 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 16 parts of radix bupleuri, 6 parts of scutellaria baicalensis, 9 parts of ginger processed pinellia tuber, 9 parts of ginger, 9 parts of aster, 9 parts of flos farae, 9 parts of blackberry lily, 6 parts of asarum, 12 parts of Chinese yam, 6 parts of immature bitter orange, 6 parts of dried orange peel and 9 parts of wrinkled gianthyssop herb. The invention combines the pneumonia symptom expression of the novel coronavirus (2019-nCoV) infection, optimizes and fuses the traditional Chinese medicine formula, and treats the pneumonia together. From the prior treatment conditions of patients with confirmed diagnosis at different ages, a plurality of provinces and a plurality of places, the curative effect is definite, and the effective rate of the treatment reaches 95.12 percent.
Description
技术领域technical field
本发明涉及中药组合物,具体地说,涉及一种治疗新型冠状病毒感染的肺炎的方剂。The present invention relates to traditional Chinese medicine compositions, in particular, to a prescription for treating pneumonia caused by novel coronavirus infection.
背景技术Background technique
2019新型冠状病毒,临时名称为2019-nCoV冠状病毒,是2019年在人体中发现的冠状病毒新毒株。该病毒症状一般为发热、乏力、干咳、逐渐出现呼吸困难,严重者表现为急性呼吸窘迫综合征,脓毒症休克,难以纠正的代谢性酸中毒和凝血功能障碍。该病毒已确认存在人传人现象,潜伏期具有传染性,所致疾病没有特异治疗方法。The 2019 novel coronavirus, tentatively named 2019-nCoV coronavirus, is a new strain of coronavirus discovered in humans in 2019. Symptoms of the virus are generally fever, fatigue, dry cough, and progressive dyspnea, and in severe cases, acute respiratory distress syndrome, septic shock, metabolic acidosis that is difficult to correct, and coagulation dysfunction. The virus has been confirmed to have human-to-human transmission, the incubation period is contagious, and there is no specific treatment for the disease.
发明内容SUMMARY OF THE INVENTION
为了解决现有技术中存在的问题,本发明的目的是提供一种治疗新型冠状病毒感染的肺炎的方剂(清肺排毒汤)及其应用。In order to solve the problems existing in the prior art, the purpose of the present invention is to provide a prescription (Qingfei Paidu Decoction) for the treatment of pneumonia caused by novel coronavirus infection and its application.
为了实现本发明目的,本发明的技术方案如下:In order to realize the purpose of the present invention, the technical scheme of the present invention is as follows:
第一方面,本发明提供一种治疗新型冠状病毒感染的肺炎的方剂,其原料包括如下重量份的中药材料:First aspect, the present invention provides a kind of prescription for the treatment of the pneumonia of novel coronavirus infection, and its raw material comprises the traditional Chinese medicine material of following weight portion:
麻黄8-10份、炙甘草5-8份、杏仁8-10份、生石膏15-30份、桂枝8-10份、泽泻8-10份、猪苓8-10份、白术8-10份、茯苓15份、柴胡15-18份、黄芩5-8份、姜半夏8-10份、生姜8-10份、紫苑8-10份、冬花8-10份、射干8-10份、细辛5-8份、山药10-14份、枳实5-8份、陈皮5-8份、藿香8-10份。8-10 parts of ephedra, 5-8 parts of Zhigancao, 8-10 parts of almond, 15-30 parts of raw gypsum, 8-10 parts of cinnamon, 8-10 parts of Alisma, 8-10 parts of Polyporus, Atractylodes 8-10 parts 15 parts of Poria, 15-18 parts of Bupleurum, 5-8 parts of Scutellaria, 8-10 parts of Ginger Pinellia, 8-10 parts of Ginger, 8-10 parts of Aster, 8-10 parts of Winter Flower, 8-10 parts of Shegan, 5-8 parts of Asarum, 10-14 parts of yam, 5-8 parts of Citrus aurantium, 5-8 parts of tangerine peel, 8-10 parts of Huoxiang.
作为优选,所述方剂的原料包括如下重量份的中药材料:麻黄9份、炙甘草6份、杏仁9份、生石膏15-30份、桂枝9份、泽泻9份、猪苓9份、白术9份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫苑9份、冬花9份、射干9份、细辛6份、山药12份、枳实6份、陈皮6份、藿香9份。Preferably, the raw materials of the prescription include the following Chinese medicinal materials by weight: 9 parts of ephedra, 6 parts of Zhigancao, 9 parts of almonds, 15-30 parts of raw gypsum, 9 parts of cinnamon sticks, 9 parts of Alisma orientalis, 9 parts of Polyporus chinensis, Atractylodes 9 parts, Poria 15 parts, Bupleurum 16 parts, Scutellaria baicalensis 6 parts, Ginger Pinellia 9 parts, Ginger 9 parts, Aster 9 parts, Donghua 9 parts, Shegan 9 parts, Asarum 6 parts, Chinese yam 12 parts, Citrus citrus 6 parts parts, 6 parts of dried tangerine peel, and 9 parts of Huoxiang.
本发明所述方剂的组方,参考中医经典著作汉代张仲景《伤寒杂病论》,由麻黄杏仁甘草石膏汤(简称麻杏石甘汤,伤寒论63)、小柴胡汤(伤寒论96)、五苓散(伤寒论71)、射干麻黄汤(金匮要略.肺萎肺痈咳嗽上气病脉证治第七)加减化裁而成。方中的山药、枳实、陈皮和藿香,是针对本次新型冠状病毒感染的肺炎临床症状加减。The composition of the prescription of the present invention, with reference to Zhang Zhongjing's "Treatise on Febrile Diseases and Miscellaneous Diseases" in the Han Dynasty, a classic Chinese medicine, is composed of Mahuang Xingxinggancaojiaotang (referred to as Maxing Shigan Decoction, Shanghan Lun 63), Xiaochaihu Decoction (Shanghan Lun 96), Wuling Powder (Treatise on Febrile Diseases 71), Shegan Mahuang Decoction (Jinkui Yaolue. Lung atrophy, abscess, cough, upper qi disease, pulse syndrome seventh) are added and subtracted. The yam, citrus aurantium, tangerine peel and huoxiang in the recipe are for the addition and subtraction of the clinical symptoms of pneumonia caused by the new coronavirus infection.
其中,麻杏石甘汤宣肺透邪;五苓散化湿祛浊,通利三焦,湿走小便,使得湿气从毛孔与小便尽除;小柴胡汤梳理少阳枢机;射干麻黄汤解表化饮下气止咳;藿香、枳实、陈皮调理脾胃气机,芳香行气化浊,使得胸腹部浊气排除而呼吸顺畅;更有山药补益脾肾,扶助正气。全方共奏祛湿化浊,清肺透邪、调和气机之效。Among them, Maxing Shigan Decoction dispels the lungs and removes pathogenic factors; Wuling Powder disperses dampness and removes turbidity, clears the triple burner, and urinates when wet, so that moisture can be completely removed from pores and urination; Xiaochaihu Decoction combs Shaoyang cardinals; Shegan Mahuang Decoction dissolves Table Hua Yin Xia Qi relieves cough; Huoxiang, Citrus aurantium, tangerine peel regulate the spleen and stomach qi machine, fragrant qi and turbidity, make the chest and abdomen turbid qi expel and smooth breathing; more yam nourishes the spleen and kidney, and supports healthy qi. The whole recipe has the effect of removing dampness and turbidity, clearing the lungs and removing pathogens, and reconciling the qi.
进一步优选,所述方剂的中药原料由如下重量份的中药材料组成:Further preferably, the traditional Chinese medicine raw material of described prescription is made up of the traditional Chinese medicine material of following weight portion:
麻黄9份、炙甘草6份、杏仁9份、生石膏15-30份、桂枝9份、泽泻9份、猪苓9份、白术9份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫苑9份、冬花9份、射干9份、细辛6份、山药12份、枳实6份、陈皮6份、藿香9份。9 parts of ephedra, 6 parts of Zhigancao, 9 parts of almonds, 15-30 parts of gypsum, 9 parts of cinnamon, 9 parts of Alisma, 9 parts of Polyporus, 9 parts of Atractylodes, 15 parts of Poria, 16 parts of Bupleurum, 6 parts of Scutellaria baicalensis , 9 parts of ginger pinellia, 9 parts of ginger, 9 parts of aster, 9 parts of winter flower, 9 parts of shegan, 6 parts of asarum, 12 parts of yam, 6 parts of citrus aurantium, 6 parts of tangerine peel, and 9 parts of Huoxiang.
其中,生石膏的用量依据患者是否发烧进行调整,如果患者不发烧则生石膏的用量要小,如果患者发烧或壮热则加大生石膏的用量。Among them, the dosage of gypsum is adjusted according to whether the patient has a fever. If the patient does not have a fever, the dosage of the gypsum should be smaller, and if the patient has a fever or strong fever, the dosage of the gypsum is increased.
进一步地,所述方剂的剂型为水煎剂。Further, the dosage form of the prescription is a water decoction.
第二方面,本发明提供了所述方剂的制备方法:将所述原料用水煎制,其中,生石膏先煎煮,再将其他中药材料(中药饮片)投入合并煎煮。In the second aspect, the present invention provides a method for preparing the formula: decoct the raw materials with water, wherein the raw gypsum is first decocted, and then other traditional Chinese medicine materials (Chinese herbal pieces) are put into and combined for decoction.
第三方面,本发明提供了所述方剂(清肺排毒汤)在制备具有清肺排毒药效的药物中的应用。In a third aspect, the present invention provides the application of the prescription (Qingfei Paidu Decoction) in preparing a medicine with the effect of clearing the lung and detoxifying.
以及,所述方剂(清肺排毒汤)在制备治疗肺炎疾病的药物中的应用。And, the application of the prescription (Qingfei Paidu Decoction) in the preparation of a medicine for treating pneumonia.
尤其是,所述肺炎为由病毒感染所致的肺炎。In particular, the pneumonia is pneumonia caused by viral infection.
所述病毒包括但不限于新型冠状病毒2019-nCoV、呼吸系统综合症冠状病毒及呼吸道合胞病毒。The viruses include but are not limited to novel coronavirus 2019-nCoV, respiratory syndrome coronavirus and respiratory syncytial virus.
经客观实验证实,本发明所述方剂对新型冠状病毒2019-nCoV感染引发的肺炎具有良好的治疗效果。Objective experiments have confirmed that the prescription of the present invention has a good therapeutic effect on pneumonia caused by novel coronavirus 2019-nCoV infection.
作为推荐,所述方剂的使用方法为:水煎服,一天一副,早晚两次(饭后四十分钟),温服。如有条件,每副药服用后服大米汤半碗,舌干津液亏虚者可多服至一碗。三副一个疗程。建议患者须按原方服满一个疗程,若症状好转而未痊愈则服用第二个疗程。若患者有特殊情况或其他基础病,第二疗程可以根据实际情况修改处方,症状消失则停药。As a recommendation, the use method of the prescription is: decoct in water, take one pair a day, twice in the morning and evening (forty minutes after meals), and take it warm. If conditions permit, take half a bowl of rice soup after taking each pair of medicines, and those with dry tongue and body fluid deficiency can take one more bowl. Three sets of one course of treatment. It is recommended that patients should take the original prescription for a full course of treatment. If the patient has special conditions or other underlying diseases, the second course of treatment can modify the prescription according to the actual situation, and stop the drug if the symptoms disappear.
另外,服用此方前若有便秘现象,须加服防风通圣丸,大便通利后停服丸药。In addition, if there is constipation before taking this prescription, you must take Fangfengtongsheng pills, and stop taking the pills after the bowel movement is clear.
本发明涉及到的原料或试剂均为普通市售产品,涉及到的操作如无特殊说明均为本领域常规操作。The raw materials or reagents involved in the present invention are all common commercially available products, and the operations involved are routine operations in the art unless otherwise specified.
在符合本领域常识的基础上,上述各优选条件,可以相互组合,得到具体实施方式。On the basis of common knowledge in the art, the above preferred conditions can be combined with each other to obtain specific embodiments.
本发明的有益效果在于:The beneficial effects of the present invention are:
本发明结合本次“新型冠状病毒肺炎”的疫病症状表现,认为新型冠状病毒(2019-nCoV)感染的肺炎属于中医“寒疫”范畴,且湿邪为盛。主要病位在肺,其次病位在表卫、脾胃;主要病因为伏燥和湿寒邪气夹杂。主要病机为疫毒湿寒与伏燥搏结,导致气机痹阻,升降失常。Combined with the symptoms of the "new coronavirus pneumonia" this time, the present invention believes that the pneumonia infected by the new coronavirus (2019-nCoV) belongs to the category of "cold epidemic" in traditional Chinese medicine, and dampness is prevalent. The main disease site is in the lungs, followed by the external defense, spleen and stomach. The main pathogenesis is the dampness and coldness of the epidemic poison and the stagnation of dryness, which leads to the obstruction of the qi machine and the abnormal rise and fall.
本发明据此提供了前述方剂,利用多种中药优化融合,共同施治。从目前多省多地不同年龄层次的确诊患者救治情况看,疗效确切。相关临床观察研究持续进行中。Accordingly, the present invention provides the aforementioned prescription, which utilizes a variety of traditional Chinese medicines for optimal fusion and joint treatment. Judging from the current treatment of confirmed patients of different ages in many provinces and places, the curative effect is definite. Relevant clinical observational studies are ongoing.
本发明所提供的方剂(清肺排毒汤)为国家中医药管理局应急科研专项“中医药防治新型冠状病毒感染的肺炎有效方剂临床筛选研究”所使用方剂,目前正结合临床救治开展临床观察工作,相关研究正持续推进。该方适用于轻型、普通型、重型患者,在危重型患者救治中也可结合患者实际情况合理使用,具有良好的社会效益。The formula (Qingfei Paidu Decoction) provided by the present invention is the formula used in the emergency scientific research project of the State Administration of Traditional Chinese Medicine "Clinical Screening Research on Effective Prescriptions for Prevention and Treatment of Novel Coronavirus Infected Pneumonia" by Traditional Chinese Medicine, and is currently carrying out clinical observation work in combination with clinical treatment. , and related research is continuing. This prescription is suitable for light, ordinary and severe patients, and can also be reasonably used in the treatment of critically ill patients in combination with the actual situation of the patients, and has good social benefits.
具体实施方式Detailed ways
下面将结合实施例对本发明的优选实施方式进行详细说明。需要理解的是以下实施例的给出仅是为了起到说明的目的,并不是用于对本发明的范围进行限制。本领域的技术人员在不背离本发明的宗旨和精神的情况下,可以对本发明进行各种修改和替换。The preferred embodiments of the present invention will be described in detail below with reference to the examples. It should be understood that the following examples are given for illustrative purposes only, and are not intended to limit the scope of the present invention. Those skilled in the art can make various modifications and substitutions to the present invention without departing from the spirit and spirit of the present invention.
下述实施例中所使用的实验方法如无特殊说明,均为常规方法。The experimental methods used in the following examples are conventional methods unless otherwise specified.
下述实施例中所用的材料、试剂等,如无特殊说明,均可从商业途径得到。The materials, reagents, etc. used in the following examples can be obtained from commercial sources unless otherwise specified.
实施例1Example 1
本实施例用于说明本发明所述方剂(清肺排毒汤)的制备方法。This example is used to illustrate the preparation method of the formula (Qingfei Paidu Decoction) of the present invention.
一、原料(以重量份计):1. Raw materials (by weight):
麻黄9份、炙甘草6份、杏仁9份、生石膏15-30份、桂枝9份、泽泻9份、猪苓9份、白术9份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫苑9份、冬花9份、射干9份、细辛6份、山药12份、枳实6份、陈皮6份、藿香9份。9 parts of ephedra, 6 parts of Zhigancao, 9 parts of almonds, 15-30 parts of gypsum, 9 parts of cinnamon, 9 parts of Alisma, 9 parts of Polyporus, 9 parts of Atractylodes, 15 parts of Poria, 16 parts of Bupleurum, 6 parts of Scutellaria baicalensis , 9 parts of ginger pinellia, 9 parts of ginger, 9 parts of aster, 9 parts of winter flower, 9 parts of shegan, 6 parts of asarum, 12 parts of yam, 6 parts of citrus aurantium, 6 parts of tangerine peel, and 9 parts of Huoxiang.
其中,生石膏的用量依据患者是否发烧在上述用量范围内进行调整,如果患者不发烧则生石膏的用量要小,如果患者发烧或壮热则加大生石膏的用量。Among them, the dosage of gypsum is adjusted within the above dosage range according to whether the patient has a fever. If the patient does not have a fever, the dosage of the gypsum should be smaller, and if the patient has a fever or strong fever, the dosage of the gypsum is increased.
二,制备方法Second, the preparation method
按照上述重量配比称取原料(中药饮片),先将生石膏置于水中煎煮,再将其他原料(中药饮片)投入合并煎煮。Weigh the raw materials (Chinese herbal medicine pieces) according to the above weight ratio, put the gypsum in water for decoction first, and then put other raw materials (Chinese herbal medicine pieces) into the mixture for decocting.
煎煮完成后,即得本发明所述方剂(清肺排毒汤)。After the decoction is completed, the prescription of the present invention (Qingfei Paidu Decoction) is obtained.
实验例1Experimental example 1
对新型冠状病毒感染的肺炎确诊病例给予实施例1制备的方剂(清肺排毒汤)尝试治疗。The prescription (Qingfei Paidu Decoction) prepared in Example 1 was given to the confirmed cases of pneumonia infected by the new coronavirus to try to treat.
水煎服,一天一副,早晚两次(饭后四十分钟),温服。如有条件,每副药服用后服大米汤半碗,舌干津液亏虚者可多服至一碗。三副一个疗程。Decoct in water, one pair a day, twice in the morning and evening (forty minutes after meals), warm. If conditions permit, take half a bowl of rice soup after taking each pair of medicines, and those with dry tongue and body fluid deficiency can take one more bowl. Three sets of one course of treatment.
截至2月5日,该方剂已在四个省36个城市37个医院246名新型冠状病毒感染的肺炎确诊病例使用,通过对乏力、发烧、咳嗽、咽痛、纳差以及影像学等症状变化情况进行综合观察,数据显示:As of February 5, the prescription has been used in 246 confirmed cases of pneumonia caused by new coronavirus infection in 37 hospitals in 36 cities in four provinces. Comprehensive observation of the situation, the data shows:
234名患者服药后有效,总有效率约为95.12%。其中,81名患者服药后症状平稳未加重,约占总观察病例的32.93%;119名患者症状改善,约占总观察病例的48.37%;24名患者症状消失,约占总观察病例的9.76%;10名患者解除隔离或出院,约占总观察病例的4.07%。234 patients were effective after taking the medicine, and the total effective rate was about 95.12%. Among them, 81 patients had stable symptoms without aggravation after taking the drug, accounting for about 32.93% of the total observation cases; 119 patients had symptoms improved, accounting for about 48.37% of the total observation cases; 24 patients had symptoms disappeared, accounting for about 9.76% of the total observation cases ; 10 patients were released from isolation or discharged, accounting for about 4.07% of the total observed cases.
病情继续发展的患者有12名(4.88%)。There were 12 patients (4.88%) whose disease continued to develop.
实施例2Example 2
本实施例与实施例1的区别在于:The difference between this embodiment and Embodiment 1 is:
原料(以重量份计):Raw materials (in parts by weight):
麻黄8份、炙甘草7份、杏仁10份、生石膏15-30份、桂枝8份、泽泻10份、猪苓10份、白术8份、茯苓14份、柴胡15份、黄芩7份、姜半夏10份、生姜8份、紫苑10份、冬花8份、射干10份、细辛5份、山药13份、枳实5份、陈皮7份、藿香10份。8 parts of ephedra, 7 parts of Zhigancao, 10 parts of almond, 15-30 parts of gypsum, 8 parts of cinnamon, 10 parts of Alisma, 10 parts of Polyporus, 8 parts of Atractylodes, 14 parts of Poria, 15 parts of Bupleurum, 7 parts of Scutellaria baicalensis , 10 parts of ginger pinellia, 8 parts of ginger, 10 parts of aster, 8 parts of winter flower, 10 parts of Shegan, 5 parts of Asarum, 13 parts of Chinese yam, 5 parts of Citrus aurantium, 7 parts of tangerine peel, 10 parts of Huoxiang.
实施例3Example 3
本实施例与实施例1的区别在于:The difference between this embodiment and Embodiment 1 is:
原料(以重量份计):Raw materials (in parts by weight):
麻黄10份、炙甘草6份、杏仁8份、生石膏15-30份、桂枝10份、泽泻8份、猪苓8份、白术10份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫苑8份、冬花9份、射干10份、细辛6份、山药12份、枳实6份、陈皮5份、藿香8份。10 parts of ephedra, 6 parts of Zhigancao, 8 parts of almond, 15-30 parts of gypsum, 10 parts of cinnamon, 8 parts of Alisma, 8 parts of Polyporus, 10 parts of Atractylodes, 15 parts of Poria, 16 parts of Bupleurum, 6 parts of Scutellaria baicalensis , 9 parts of ginger pinellia, 9 parts of ginger, 8 parts of aster, 9 parts of winter flower, 10 parts of shegan, 6 parts of asarum, 12 parts of yam, 6 parts of citrus aurantium, 5 parts of tangerine peel, 8 parts of Huoxiang.
实施例4Example 4
本实施例与实施例1的区别在于:The difference between this embodiment and Embodiment 1 is:
原料(以重量份计):Raw materials (in parts by weight):
麻黄9份、炙甘草6份、杏仁10份、生石膏15-30份、桂枝9份、泽泻9份、猪苓10份、白术10份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜8份、紫苑9份、冬花10份、射干9份、细辛6份、山药12份、枳实5份、陈皮6份、藿香9份。9 parts of ephedra, 6 parts of Zhigancao, 10 parts of almonds, 15-30 parts of gypsum, 9 parts of cinnamon, 9 parts of Alisma, 10 parts of Polyporus, 10 parts of Atractylodes, 15 parts of Poria, 16 parts of Bupleurum, 6 parts of Scutellaria baicalensis , 9 parts of ginger pinellia, 8 parts of ginger, 9 parts of aster, 10 parts of winter flowers, 9 parts of shegan, 6 parts of asarum, 12 parts of yam, 5 parts of citrus aurantium, 6 parts of tangerine peel, and 9 parts of Huoxiang.
虽然,上文中已经用一般性说明及具体实施方案对本发明作了详尽的描述,但在本发明基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。Although the present invention has been described in detail above with general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention fall within the scope of the claimed protection of the present invention.
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20220137663A (en) | 2022-10-12 |
| WO2021155751A1 (en) | 2021-08-12 |
| CN110870402B (en) | 2020-07-17 |
| TW202140053A (en) | 2021-11-01 |
| JP7424684B2 (en) | 2024-01-30 |
| CA3168659A1 (en) | 2021-08-12 |
| TWI792162B (en) | 2023-02-11 |
| JP2023512529A (en) | 2023-03-27 |
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