Humans are Capable of Greatness | Capable

We spend a third of our lives asleep. Yet, a small subset of humans thrive on four to six hours of sleep per night. They carry short sleeper variants, allowing them to remain healthy while being awake for longer. Previous research reports those short sleepers to have more energy, vigor, and disease resistance. While not definitive evidence, we see them as a proof-of-concept for our biggest frontier for improving human health.

Our first four programs are in sleep. Concretely, we are first working on therapeutics that restore cognitive performance under sleep deprivation, and then towards the end-goal of allowing patients to sleep 1-2 hours less. Our initial focus will be on rare, undertreated sleep diseases like narcolepsy and hypersomnia, while gradually expanding to a broader population, via shift-work sleep disorders.