Cancel Death — What changed in longevity science

Cancel Death

6 min read Original article ↗

What matters now

Important findings, useful explanations, and setbacks worth knowing about.

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7 stories from the past 72 hours. Older stories keep their original dates. Ranking reflects relevance, recency and reader interest—not proof of benefit.

Longevity news

News, research and the studies that currently shape the longevity chart—all in one stream.

  4. Research affecting the chart· PubMed

    Combined lifestyle factors, all-cause mortality and cardiovascular disease

    Published 2020Observational researchGeneral adult evidence

    Directly changes the Combined lifestyle chart input

    74 studies; 2,584,766 participants in the all-cause mortality analysis.

    Study scope and limits

    Adults in prospective cohorts; populations and lifestyle definitions varied.

    Healthiest versus least-healthy combinations of smoking, activity, diet, weight and alcohol factors.

    Observational association, with residual confounding and heterogeneous lifestyle scores. Not the effect of changing an average person’s habits. Alcohol in the score is not a recommendation to drink.

    Read the study · PubMed ↗

  7. Research affecting the chart· PubMed

    Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality

    Published 2025Observational researchGeneral adult evidence

    Directly changes the Physical activity chart input

    Umbrella review of meta-analyses; equivalent hazard ratio for leisure-time physical activity.

    Study scope and limits

    Adults in the self-reported leisure-time physical activity syntheses.

    Higher versus lower self-reported leisure-time physical activity; contrasts vary across studies.

    Authors classify the association as suggestive evidence. Self-report, residual confounding and overlapping reviews limit interpretation. Replaces the combined lifestyle estimate rather than stacking on it.

    Read the study · PubMed ↗

  9. News coverage· The Guardian

    News outlet asks readers about shingles vaccine and dementia hopes

    Published Sep 29, 2026Added 2dStart a discussion

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    A media outlet is soliciting reader experiences about getting the shingles vaccine based on hopes it might lower dementia risk, noting that vaccine sales have increased following studies suggesting a potential link.

    Why it matters: Reports of vaccine interest show how research findings influence public health decisions.

    AI-assisted explanation · Source coverage · not an evidence rating

    Read the article · The Guardian ↗

  10. Research affecting the chart· PubMed

    Efficacy and safety of more intensive lowering of LDL cholesterol

    Published 2010Randomized researchCardiovascular prevention trial populations

    Directly changes the Statins chart input

    CTT individual participant meta-analysis of 26 trials; about 170,000 participants overall.

    Study scope and limits

    Participants enrolled in randomized LDL-lowering trials, with varied cardiovascular risk.

    Per 1 mmol/L lower LDL cholesterol, across statin versus control and more- versus less-intensive regimens.

    Mortality rate ratio is treated as a proportional hazard multiplier in this model. Trial populations and LDL changes differ; not a longevity estimate for healthy people or a prescribing recommendation.

    Read the study · PubMed ↗

  11. News coverage· The Guardian

    Double-dipping transmits mouth bacteria to shared dips

    Published Sep 28, 2026Added 4dStart a discussion

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    Eating part of food and redipping it into communal dip transfers bacteria from your mouth into the shared food. A study found bacteria transferred to salsa, chocolate sauce, and cheese dip, with salsa showing the most contamination.

    Why it matters: Understanding this transmission route helps reduce illness risk when sharing food with others.

    AI-assisted explanation · Source coverage · not an evidence rating

    Read the article · The Guardian ↗

  12. News coverage· The Guardian

    GLP-1 drugs may cause hair shedding in some users

    Published Sep 27, 2026Added 4dStart a discussion

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    A survey found 20% of GLP-1 users experienced hair shedding, but high-quality controlled trials haven't confirmed how often this occurs.

    Why it matters: Millions use these medications, so understanding potential side effects helps people make informed treatment decisions.

    AI-assisted explanation · Source coverage · not an evidence rating

    Read the article · The Guardian ↗

  13. Research affecting the chart· PubMed

    Cardiovascular and Kidney Outcomes and Mortality With Long-Acting GLP-1 Receptor Agonists

    Published 2025Randomized researchType 2 diabetes trial populations

    Directly changes the GLP-1 agonists chart input

    10 randomized trials; 71,351 participants.

    Study scope and limits

    People with type 2 diabetes in large cardiovascular and kidney outcome trials.

    Long-acting GLP-1 receptor agonist versus placebo, on top of trial background care.

    Class-level synthesis in type 2 diabetes; not transferable to healthy adults, every agent, or lifelong use. Trials already include other care, so combining effects can double-count benefit.

    Read the study · PubMed ↗

  15. Research affecting the chart· journals.plos.org

    SGLT2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes

    Published 2023Randomized researchChronic kidney disease trial populations

    Directly changes the SGLT2 inhibitors chart input

    Systematic review of 14 randomized trials; all-cause mortality is a secondary endpoint.

    Study scope and limits

    People with chronic kidney disease, with or without type 2 diabetes.

    SGLT2 inhibitor plus standard therapy versus placebo or standard therapy.

    The 14 trials cover the review as a whole, not necessarily this endpoint. Kidney disease populations differ from the reference life table. Background treatment overlaps with other selections.

    Read the study · journals.plos.org ↗
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