Browse Articles | Nature Methods

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  • Optical boxcar-enhanced fluorescence-detected mid-infrared photothermal microscopy (FILM), together with artificial intelligence-assisted data processing, maps the chemical composition of individual cell organelles in their native context. This technique uncovered metabolic heterogeneity of lysosomes and lysosomal changes during physiological aging and pathological conditions.

    Research Briefing

  • ArticleOpen Access

  • It is not certain that everything is uncertain. —Blaise Pascal

    • Christoph F. Kurz
    • Martin Krzywinski
    • Naomi Altman

    This Month

  • AI agent systems are now being built on top of large language models, and they can conduct autonomous analyses. Choosing among the offerings takes a balance of curiosity, excitement and skepticism.

    • Vivien Marx

    Technology Feature

  • ArticleOpen Access

  • Brief CommunicationOpen Access

  • Research Briefing

  • ArticleOpen Access

  • ArticleOpen Access

  • Brief Communication

  • Correspondence

  • The open-source Orthrus RNA language model maps evolutionary patterns across mammalian species to predict key mRNA properties, advancing RNA biology research.

    • Jun Wang
    • Dinghai Zheng
    • Vikram Agarwal

    News & Views