Endowing cells with logic and memory

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Nature Biotechnology volume 31, pages 413–415 (2013)Cite this article

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Genetic circuits that process and permanently store information are created with recombinases that flip the orientation of DNA cassettes.

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Figure 1: An integrated logic and memory device.

References

  1. Adleman, L.M. et al. J. Comput. Biol. 6, 53–63 (1999).

    Article  CAS  Google Scholar 

  2. Purnick, P.E. & Weiss, R. Nat. Rev. Mol. Cell Biol. 10, 410–422 (2009).

    Article  CAS  Google Scholar 

  3. Siuti, P. et al. Nat. Biotechnol. 31, 448–452 (2013).

    Article  CAS  Google Scholar 

  4. Weber, W. & Fusseneger, M. Chem. Biol. 16, 287–297 (2009).

    Article  CAS  Google Scholar 

  5. Yamamoto, S. & Kutsukake, K. J. Bacteriol. 188, 958–967 (2006).

    Article  CAS  Google Scholar 

  6. Bonnet, J. et al. Science doi:10.1126/science.1232758 (28 March 2013).

  7. Friedland, A.E. et al. Science 324, 1199–1202 (2009).

    Article  CAS  Google Scholar 

  8. Livet, J. et al. Nature 450, 56–62 (2007).

    Article  CAS  Google Scholar 

  9. Gardner, T.S. et al. Nature 403, 339–342 (2000).

    Article  CAS  Google Scholar 

  10. Barrangou, R. et al. Science 315, 1709–1712 (2007).

    Article  CAS  Google Scholar 

  11. Qi, L.S. et al. Cell 152, 1173–1183 (2013).

    Article  CAS  Google Scholar 

  12. Zanton, S. & Pugh, B.F. Genes Dev. 20, 2250–2265 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Andre C. Maranhao & Andrew D. Ellington are at the Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA.,

    Andre C Maranhao & Andrew D Ellington

Authors

  1. Andre C Maranhao
  2. Andrew D Ellington

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Correspondence to Andrew D Ellington.

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The authors declare no competing financial interests.

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Maranhao, A., Ellington, A. Endowing cells with logic and memory. Nat Biotechnol 31, 413–415 (2013). https://doi.org/10.1038/nbt.2573

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