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Nature Podcast
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The dynamic basis of G-protein recognition and activation by a GPCR
Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.
- Kazuhiro Kobayashi
- Kouki Kawakami
- Hideaki E. Kato
Article
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A large-scale coherent 4D imaging sensor
A 4D imaging architecture using a large-scale, coherent LiDAR focal plane array comprising more than 0.6 million photonic components and associated electronics integrated on-chip can obtain coherent images at high frame rates over useful distances.
- Francesca Fabiana Settembrini
- Arif Can Gungor
- Remus Nicolaescu
ArticleOpen Access
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Capturing dynamic phage–pathogen coevolution by clinical surveillance
The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are captured, revealing the molecular basis of the natural selection of a globally notable pathogen and its virus.
- Yamini Mathur
- Caroline M. Boyd
- Kimberley D. Seed
ArticleOpen Access
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Multidimensional profiling of heterogeneity in supratentorial ependymomas
Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.
- Daeun Jeong
- Sara G. Danielli
- Mariella G. Filbin
ArticleOpen Access
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ArticleOpen Access
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ArticleOpen Access
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Lense–Thirring precessing magnetar engine drives a superluminous supernova
Observations of a nearby type I superluminous supernova showing oscillating light-curve bumps provide evidence of a centrally located magnetar in the wake of the explosion, surrounded by an infalling accretion disk undergoing Lense–Thirring precession.
- Joseph R. Farah
- Logan J. Prust
- Peter Blanchard
Article
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ArticleOpen Access
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Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity
Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.
- Alina A. Vo
- Arnab Modak
- Michael J. Robertson
ArticleOpen Access
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ArticleOpen Access
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ArticleOpen Access
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ArticleOpen Access
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ArticleOpen Access
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Nanophotonic waveguide chip-to-world beam scanning
A monolithically integrated photonic ski-jump enables scalable, diffraction-limited 2D beam scanning from photonic chips, achieving ultrahigh spot rates, compact footprints and applications spanning displays, sensing and quantum photonics.
- Matt Saha
- Y. Henry Wen
- Dirk Englund
ArticleOpen Access
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ArticleOpen Access