However, WebOS failed to gain traction with reviewers, operators and retailers.
The decision to ditch the Pre, as well as its TouchPad tablet computers, comes despite paying $1.2bn (£727m) last year to buy up the technology through its acquisition of Palm.
There have been long-running rumours that chief executive Leo Apotheker, who recently joined from German rival SAP, wanted to refocus the company away from its traditional hardware business towards its smaller, but much more profitable, software lines.
The transformation planned by Mr Apotheker mirrors that of IBM, which dropped out of its traditional hardware business over the past decade.
"HP is recognising what the world has recognised, which is hardware in terms of consumers is not a huge growth business anymore," said Michael Yoshikami, chief executive of YCMNET Advisors.
"It's not where the money is. It's in keeping with the new CEO's perspective that they want to be more in services and more business-oriented."
On the sale of its PC business, HP said it "will consider a broad range of options that may include, among others, a full or partial separation... from HP through a spin-off or other transaction".
Market rumours have previously named various private equity firms as being keen to buy parts of HP if a break-up of the company were to happen.