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We back the rare humans with the grit to solve the toughest challenges.

Accelerating solutions in Healthcare & Life Sciences, Security & Resiliency, Sustainable Food Systems, Climate, and Global Financial Systems.

We back the rare humans with the grit to solve the toughest challenges.

Accelerating solutions in Healthcare & Life Sciences, Security & Resiliency, Sustainable Food Systems, Climate, and Global Financial Systems.

Follow-on Capital Raised

$ 0 B

Different by Design

Since 2009, we’ve built a formidable global network and we’re obsessive about giving founders breakthrough access to the people and power that move markets. Corporates, customers, regulators, funders—leaders who understand complexity and help you scale what truly matters.

FOUNDERS

Founders need more than capital. They need access, insight, and relationships that unlock momentum. We accelerate those connections through proven programs, giving you the leverage to move faster and go further.

EXPERTS

Our experts—founders, operators, researchers, and industry leaders—support you at critical inflection points, Their real-world insight sharpens your roadmap: technical, go-to-market, or team. Every connection delivers high-impact access when it matters most.

COLLABORATORS

Our collaborators know progress demands more than optimism. Together, we work to reshape the systems founders rely on, whether capital, policy, and industry, especially where barriers are steepest. We ensure founders have the support they need to reach scale.

Real words from the founders redefining what's possible.

MassChallenge has been incredible for us. It’s hard to be an entrepreneur, especially in climate, and the programming helped us see that we’re not the only ones in this. One of the main learnings I’ve gotten from this program is that impact and profitability are not mutually exclusive.

dgory

Founder and CEO at Airbuild

I wouldn’t just say this was something that I needed professionally, but on a personal level too. It’s about you as a person first. The people at MassChallenge and this community made me feel confident stepping into healthcare in a way I wasn’t before.

kylehenry

CEO and Co-Founder, Tune Health

MassChallenge has been an incredible opportunity for us. It’s rare for a startup at our stage to work directly with enterprise partners. Through the program, we’ve been able to engage with enterprise users early on, understand their pain points, and build better solutions. Over the past few months, we’ve taken our product from prototype to production-ready, and without MassChallenge, this progress wouldn’t have been possible.

ShuaiLi

It takes a community to raise a startup. You can be deep in technology, but you need the network, the right advisors, and the right connections. That’s what MassChallenge brought, and it made something complex feel executable.

RWHITTAKER

CEO and CoFounder of AirShare

I am so excited for the networking we’ve gone through. Together it takes all of us to make the world a better place. If you’re looking for the networking and the connections and the people that will help you take your company to the next level, this is one of the most worthwhile programs.

jimboyte

Founder & CEO at ActiveDefender

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For questions about our programs, contact programs@masschallenge.org.