Toxic Proteins for Drug Discovery

asimov.press

13 points by mailyk 4 days ago


JSR_FDED - 2 days ago

> While semaglutide is the current cause célèbre among therapeutic peptides, the power of GLP-1 mimicking drugs was first realized in a hormone isolated from the venom of the Gila Monster, a large lizard that lives in the Sonoran Desert. Owing to the unpredictability and harshness of that environment, these lizards are the ultimate intermittent fasters. They can go months at a time between meals, necessitating keeping their metabolism and blood sugar levels low

This is a fascinating article. Dozens of new ways to die :-) I hadn’t thought of nature as an R&D laboratory that has been running for 4.5 billion years