Melatonin may decrease risk for and aid treatment of Covid-19
openheart.bmj.comWhat if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects.
Sleep length/quality should have been taken into account.
Have scientists rediscovered the importance of sleep?
This is, of course, the right question to ask. The good thing is, we can still reasonably act on this data while we wait for more studies to disentangle the cause/correlation relationship. Melatonin is well tolerated, and also produced endogenously, so the risk/reward on this treatment is in our favor.
Well, we could turn your question around. What if it is not sleep itself, but the fact that it is related to the release of melatonin which potentially mediates immune system responses and inflammation?
The paper offers interesting hypothesis into why this could be the case.
The study is of intubated patients, I think they're asleep a lot...
But I'm sure poor sleep habits are a risk factor for severe Covid anyway.
And that's not what melatonin does.
> A retrospective analysis of 791 intubated patients with COVID-19 has found that, after adjustment for pertinent demographics and comorbidities, those treated with melatonin had a markedly lower risk for mortality (HR: 0.131, 95% CI: 0.076 to 0.223)—suggestive of a profound anti-inflammatory benefit.
> Moreover, recent epidemiology suggests that melatonin usage may reduce the risk for contracting COVID-19. A recent retrospective study, examining data from 26 799 subjects in a COVID-19 registry and using propensity score matching to account for a range of covariates, found that current supplementation with melatonin was associated with a significant 28% reduction in risk for serologically detectible COVID-19 infection. Among Black Americans, this reduction in risk was a remarkable 52% (OR=0.48, 95% CI 0.31 to 0.75).
> More generally, it might be feasible to define a simple nutraceutical regimen that could reduce the risk for COVID-19 and a range of other viral infections. There is growing evidence, both case–control and ecologic, that replete vitamin D status not only markedly improves the clinical course of COVID-19, but also is associated with decreased risk for clinically detectible infection.
> COVID-19 epidemiology also suggests that higher zinc status is associated with both a better clinical course in this disorder and lower risk for infection.42 43 Especially in the elderly, who are more prone to poor zinc status, zinc supplementation has been found to boost acquired, antigen-specific immunity, while also exerting an anti-inflammatory action; such supplementation of the elderly was associated with a marked decrease in total infections in a 12-month randomised controlled trial.
> Hence, it is not unreasonable to suggest that a supplementation programme incorporating vitamin D, zinc, melatonin and possibly additional nutraceuticals could reduce risk for and aid control of COVID-19 and a range of other viral infections.
After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.
I totally agree with your point re: the need for data. I would push back a bit on the rhetorical issues with conflating traditional 'antivaxxers' with everyone who may be skeptical of these vaccines. It's not clear that these issues can be meaningfully grouped together on an ontological level.
Sorry about that. It isn't really anything to do with the vaccines. It is simply something that may help others, since some unfortunate few (very small %) are even getting "long covid" from just the vaccine alone.
Niacin appears to be very well studied, but not in the context of post-viral illnesses. But there are a mountain of papers which may help to explain why it works. Here are a few:
Underlying lack of niacin and establish indicated use: https://academic.oup.com/bib/article/22/2/1279/5964187 https://clinmedjournals.org/articles/jide/journal-of-infecti...
Lipids in covid: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869689/ Sars CoV 2 entry to cells: https://www.nature.com/articles/s42255-020-00324-0 Replication etc: https://journals.plos.org/plospathogens/article?id=10.1371/j... Nicotinic acid’s effects on lipids: https://www.eurekaselect.com/126340/article
Whats the mechanism for long covid from vaccines? Didn't think any of the links mentioned that.
No idea - I haven't even seen it officially recognized, or studied. But I can guess its all to do with the spike protein.
Why do you hate free speech and open discussion?
Why do you hate antivaxxers - are you trained in medicine, molecular biology, etc. or is this nothing more than orthodox ideological position?
The scientific method and science itself is NEVER SETTLED. And it is always advanced from discussion including anecdotes that become more formal research.
Can you give some information or links to what was the dosage and frequency?
Up to 1000mg once per day now, but had to work up slowly over a couple of months, as I wasn't able to tolerate even 10mg at first. You need the "flushing" type of nicotinic acid (it causes your skin to go hot and red for about half an hour, but tolerance of this gradually increases), avoid the "slow release" or "non-flushing" forms of Nicotinic acid. For melatonin I started on 3mg and worked up to 9mg.